A genome-wide analysis of parasitic fitness in the Dutch elm disease fungus Ophiostoma novo-ulmi

荷兰榆树病真菌 Ophiostoma novo-ulmi 寄生适应性的全基因组分析

• 批准号: 105519-2013
• 负责人: Bernier, Louis
• 金额: $ 2.91万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545165
• 关键词: genome; wide; analysis; parasitic; fitness

More than one billion elms have been killed by two successive pandemics of Dutch elm disease (DED) since the early 20th century. The highly aggressive fungus Ophiostoma novo-ulmi is responsible for the current DED pandemic and has had a dramatic impact on populations of Ulmus americana, the most widespread native elm species in North America. Understanding the genetic basis of the host-pathogen interaction leading to DED is basic to developing control methods involving manipulation of the pathogen or its host. The general objective of the proposed research is to identify, characterize and manipulate genes that contribute to overall parasitic fitness in O. novo-ulmi. More specifically, we are targeting genes involved in pathogenicity, as well as genes that control the transition between the two growth forms (yeast and mycelium) observed in the DED fungi when they develop in their host.

自20世纪世纪以来，荷兰榆树病（DED）连续两次大流行已造成10亿多榆树死亡。高度侵袭性的真菌Ophiostoma novo-ulmi是导致目前DED大流行的原因，并对北美分布最广的本土榆树物种美洲榆（Ulmus americana）的种群产生了巨大影响。了解导致DED的宿主-病原体相互作用的遗传基础是开发涉及操纵病原体或其宿主的控制方法的基础。这项研究的总体目标是鉴定、表征和操纵影响O.新乌尔米。更具体地说，我们正在靶向参与致病性的基因，以及控制DED真菌在宿主中发育时观察到的两种生长形式（酵母和菌丝体）之间过渡的基因。