Protein and amino acid metabolism in malnutrition and metabolic stress

营养不良和代谢应激中的蛋白质和氨基酸代谢

• 批准号: 183710-2009
• 负责人: Wykes, Linda
• 金额: $ 3.86万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545941
• 关键词: Protein; amino; acid; metabolism; malnutrition

The synergistic interaction of malnutrition with infections is a complex multifactorial problem with devastating impact worldwide. Inflammation and activation of the immune system, which are both normal responses to tissue injury and infection, result in 1) increased synthesis of glutathione (GSH) to balance the increased production of free radicals and 2) increased synthesis of acute phase proteins. Both responses result in increased demands for a potentially meagre supply of amino acids. During malnutrition these responses may further compromise growth and may be compromised themselves. Our new stable isotope techniques to measure tissue protein synthesis as well as synthesis of GSH and individual plasma proteins allow comprehensive examination of the mechanisms of how pools of individual proteins or products of amino acids are maintained, augmented or depleted in states of malnutrition and/or oxidative stress.

营养不良与感染的协同作用是一个复杂的多因素问题，在世界范围内具有毁灭性影响。炎症和免疫系统的激活都是对组织损伤和感染的正常反应，导致1)谷胱甘肽(GSH)的合成增加，以平衡自由基的产生，2)急性期蛋白质的合成增加。这两种反应都导致对潜在稀缺氨基酸的需求增加。在营养不良期间，这些反应可能会进一步损害增长，本身也可能受到影响。我们新的稳定同位素技术用于测量组织蛋白质合成以及谷胱甘肽和单个血浆蛋白质的合成，使我们能够全面检查单个蛋白质或氨基酸产品池在营养不良和/或氧化应激状态下如何维持、增加或耗尽的机制。