Virus-host interactions: induction of cytotoxic T cells immune responses via the direct and alternative MHC class I presentation pathways

病毒-宿​​主相互作用：通过直接和替代 MHC I 类呈递途径诱导细胞毒性 T 细胞免疫反应

• 批准号: 311779-2010
• 负责人: Basta, Sameh
• 金额: $ 1.97万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548502
• 关键词: Virus; host; interactions; induction; cytotoxic

During virus infections, the immune system utilizes various defense elements that interact together to clear the infection. A central aspect in understanding host immunity to virus infections focuses on the interaction of the virus with host immune cells such as the macrophages and dendritic cells. These cells are known as professional antigen-presenting cells (pAPCs) because they present molecules from the virus on their cell surface and initiate the activation of cytotoxic killer cells.

在病毒感染过程中，免疫系统利用各种相互作用的防御元素来清除感染。理解宿主对病毒感染的免疫的一个中心方面集中在病毒与宿主免疫细胞如巨噬细胞和树突细胞的相互作用。这些细胞被称为专职抗原呈递细胞（pAPC），因为它们在其细胞表面上呈递来自病毒的分子并启动细胞毒性杀伤细胞的激活。