"Multimodal Optical Imaging Endoscopy for Noninvasive ""Optical Biopsy"" in Tissues"

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Lung cancer is the foremost cause of cancer death in Canada. In 2011, lung cancer is estimated to account for 11,300 of cancer deaths in men and 9,300 in women. Early detection and treatment has the potential to greatly improve these statistics. The current gold standard of cancer diagnosis is tissue biopsy followed by histopathology. In this procedure, clinicians take multiple tissue biopsies from suspicious areas and perform histopathology examination. This procedure is invasive and time consuming. "Optical biopsy" is a new type of tool which uses optical imaging to examine subcellular tissue morphology in vivo. It can provide the same imaging resolution as histopathology but the procedure is noninvasive and in real-time. Therefore, "optical biopsy" can potentially have a huge impact on the diagnosis and treatment of cancer and other diseases.