Handheld Multiphoton Imaging Device for Detecting Oral Cancer

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According to the Canadian Cancer Society, the 5-year survival rate for oral cancer is only**63%. Each year 4,600 new cases in Canada and 300,000 cases worldwide are identified and**on average, half of the patients die within 5 years of diagnosis. The recurrence rate of oral**cancer after surgery is high at 20%. Therefore, there is a critical need for new technology that**can improve the early detection and treatment of oral cancer. In this project, a new point-ofcare**cancer imaging device based on multiphoton imaging will be developed to provide highresolution**imaging of oral mucosa lesions in vivo and in real-time. Multiphoton imaging can**provide visualization of important biomarkers for cancer detection: the morphological changes**of tumor cells and nuclei, and the density and ordering of the underlying collagen fibers which**facilitates the progression and invasion of tumor cells. It has been demonstrated to be very**successful in pre-clinical cancer studies on animal models. Translating multiphoton imaging**into clinical applications is just beginning. Challenges include handling femtosecond pluses**and limited signal to noise ratio. We will address those challenges and design a portable**multiphoton system with a handheld probe for performing in vivo imaging of the oral mucosa.**In vivo imaging on patients will be carried out to evaluate the device for guided biopsy and**tumor margin detection. The new technology can improve cancer management by real-time**assessment of tumor noninvasively and guiding decisions on when and where to take**biopsies for early cancer detection.