Economical production of biobutanol through genetic engineering of Clostridium acetobutylicum for effective dissimilation of cheap feedstock
通过丙酮丁醇梭菌基因工程经济生产生物丁醇,有效异化廉价原料
基本信息
- 批准号:430106-2012
- 负责人:
- 金额:$ 11.8万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Strategic Projects - Group
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The resource depletion and environmental impacts associated with fossil fuels necessitate the search for sustainable biofuels. Up to now, ethanol appears to be the only and most popular biofuel with justified applications though it still cannot economically compete with fossil fuels without government supplements. For most biofuels currently under active exploration (including ethanol, hydrogen, butanol, biodiesel, biogas, etc.), there are two major issues to be addressed. The first is reducing feedstock cost which often represents the major part of biofuel production, whereas the second is developing an effective conversion platform based on clean production technologies. Unfortunately, these two issues are often mutually intertwined and contradictory. Hence, a true solution to the development of practical biofuel products and technologies requires a more systematic approach which simultaneously addresses these two issues. The proposed research targets the development of novel microbial strains and bioprocessing strategies to produce clean, renewable, and sustainable biofuel (i.e. n-butanol) based on the conversion of cheap feedstock (i.e. glycerol and cellulose). Hence, it will significantly enhance Canada's fuel economy, air quality, and biomanufacturing capacity, leading to the improvement of the quality of life. We will play a pivotal role to ensure the success of the proposed project through seamless and synergistic integration of various biotechniques, including microbial biotechnology, molecular biology, biochemical and bioprocess engineering. The project provides a unique multidisciplinary training program connecting fundamental science and applied industrial technology and trainees involved in this project will be among the highly qualified people that are needed to develop Canada's biomanufacturing industry.
与化石燃料相关的资源枯竭和环境影响需要寻找可持续的生物燃料。到目前为止,乙醇似乎是唯一和最受欢迎的生物燃料与合理的应用,但它仍然不能在经济上与化石燃料竞争,没有政府的补充。对于目前正在积极探索的大多数生物燃料(包括乙醇、氢气、丁醇、生物柴油、沼气等),有两个主要问题需要解决。第一个是降低原料成本,这通常是生物燃料生产的主要部分,而第二个是开发基于清洁生产技术的有效转化平台。不幸的是,这两个问题往往相互交织和矛盾。因此,开发实用生物燃料产品和技术的真正解决方案需要同时解决这两个问题的更系统的方法。拟议的研究目标是开发新型微生物菌株和生物加工策略,以基于廉价原料(即甘油和纤维素)的转化来生产清洁,可再生和可持续的生物燃料(即正丁醇)。因此,它将大大提高加拿大的燃油经济性,空气质量和生物制造能力,从而提高生活质量。我们会发挥关键作用,确保拟议项目成功进行,把各种生物技术(包括微生物生物技术、分子生物学、生化及生物过程工程)紧密结合,发挥协同作用。该项目提供了一个独特的多学科培训计划,将基础科学和应用工业技术联系起来,参与该项目的学员将成为发展加拿大生物制造业所需的高素质人才。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chou, CPerry其他文献
Chou, CPerry的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chou, CPerry', 18)}}的其他基金
Strain engineering and bioprocessing strategies for bio-based production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) using cheap feedstocks
使用廉价原料生物生产聚(3-羟基丁酸酯-co-3-羟基戊酸酯)(PHBV)的菌株工程和生物加工策略
- 批准号:
539590-2019 - 财政年份:2020
- 资助金额:
$ 11.8万 - 项目类别:
Alliance Grants
Strain engineering and bioprocessing strategies for bio-based production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) using cheap feedstocks
使用廉价原料生物生产聚(3-羟基丁酸酯-co-3-羟基戊酸酯)(PHBV)的菌株工程和生物加工策略
- 批准号:
539590-2019 - 财政年份:2019
- 资助金额:
$ 11.8万 - 项目类别:
Alliance Grants
Integration of strain engineering with bioprocess engineering strategies to enhance biobased production of value-added chemicals
将菌株工程与生物过程工程策略相结合,以增强增值化学品的生物基生产
- 批准号:
RGPIN-2019-04611 - 财政年份:2019
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Engineer Escherichia coli for 1-propanol production by integrating novel biotechnological and bioprocessing strategies
通过整合新颖的生物技术和生物加工策略,改造大肠杆菌以生产 1-丙醇
- 批准号:
RGPIN-2014-05568 - 财政年份:2018
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Engineer Escherichia coli for 1-propanol production by integrating novel biotechnological and bioprocessing strategies
通过整合新颖的生物技术和生物加工策略,改造大肠杆菌以生产 1-丙醇
- 批准号:
RGPIN-2014-05568 - 财政年份:2017
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Engineer Escherichia coli for 1-propanol production by integrating novel biotechnological and bioprocessing strategies
通过整合新颖的生物技术和生物加工策略,改造大肠杆菌以生产 1-丙醇
- 批准号:
RGPIN-2014-05568 - 财政年份:2016
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Genetic construction of novel microbial strains for biomanufacturing purposes using methanol as the feedstock
以甲醇为原料的生物制造用新型微生物菌株的遗传构建
- 批准号:
484929-2015 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Engage Grants Program
Engineer Escherichia coli for 1-propanol production by integrating novel biotechnological and bioprocessing strategies
通过整合新颖的生物技术和生物加工策略,改造大肠杆菌以生产 1-丙醇
- 批准号:
RGPIN-2014-05568 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Engineer Escherichia coli for 1-propanol production by integrating novel biotechnological and bioprocessing strategies
通过整合新颖的生物技术和生物加工策略,改造大肠杆菌以生产 1-丙醇
- 批准号:
RGPIN-2014-05568 - 财政年份:2014
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
Molecular and bioprocessing strategies in posttranslational processing to enhance recombinant protein production
翻译后加工中提高重组蛋白产量的分子和生物加工策略
- 批准号:
283237-2009 - 财政年份:2013
- 资助金额:
$ 11.8万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
交货期敏感的单件模式产品供应链的协调优化
- 批准号:70871060
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:面上项目
供应链中生产和配送联合排序和调度的模型、算法及应用
- 批准号:70372058
- 批准年份:2003
- 资助金额:14.0 万元
- 项目类别:面上项目
相似海外基金
An improved synthetic biology toolbox for developing Clostridium sp as hosts for biobutanol and commodity chemical production.
改进的合成生物学工具箱,用于开发梭状芽胞杆菌作为生物丁醇和商品化学品生产的宿主。
- 批准号:
BB/M016331/1 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Training Grant
An improved synthetic biology toolbox for developing Clostridium sp as hosts for biobutanol and commodity chemical production
改进的合成生物学工具箱,用于开发梭状芽胞杆菌作为生物丁醇和商品化学品生产的宿主
- 批准号:
1643016 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Studentship
Biobutanol production from crude glycerol, the by-product of biodiesel production
从生物柴油生产的副产品粗甘油生产生物丁醇
- 批准号:
453296-2013 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Collaborative Research and Development Grants
Genetic engineering and strain optimization of Clostridium ljungdahlii for the production of biobutanol by syngas fermentation
合成气发酵生产生物丁醇的杨氏梭菌基因工程及菌株优化
- 批准号:
274455180 - 财政年份:2015
- 资助金额:
$ 11.8万 - 项目类别:
Research Fellowships
Biobutanol production from crude glycerol, the by-product of biodiesel production
从生物柴油生产的副产品粗甘油生产生物丁醇
- 批准号:
453296-2013 - 财政年份:2014
- 资助金额:
$ 11.8万 - 项目类别:
Collaborative Research and Development Grants
BRIGE: Metabolic Cell-Process Engineering (MCPE) for High Biobutanol Production by Clostridium tyrobutyricum
BRIGE:酪丁酸梭菌高生物丁醇生产的代谢细胞过程工程 (MCPE)
- 批准号:
1342390 - 财政年份:2014
- 资助金额:
$ 11.8万 - 项目类别:
Standard Grant
13TSB_SynBio- Novel Bacterial Hosts for Biobutanol Production
13TSB_SynBio-用于生物丁醇生产的新型细菌宿主
- 批准号:
BB/L004356/1 - 财政年份:2013
- 资助金额:
$ 11.8万 - 项目类别:
Research Grant
Engineering A Novel Bacterial Host for Biobutanol Production
设计用于生物丁醇生产的新型细菌宿主
- 批准号:
131180 - 财政年份:2013
- 资助金额:
$ 11.8万 - 项目类别:
Feasibility Studies
Economical production of biobutanol through genetic engineering of Clostridium acetobutylicum for effective dissimilation of cheap feedstock
通过丙酮丁醇梭菌基因工程经济生产生物丁醇,有效异化廉价原料
- 批准号:
430106-2012 - 财政年份:2013
- 资助金额:
$ 11.8万 - 项目类别:
Strategic Projects - Group
Biobutanol production from crude glycerol, the by-product of biodiesel production
从生物柴油生产的副产品粗甘油生产生物丁醇
- 批准号:
453296-2013 - 财政年份:2013
- 资助金额:
$ 11.8万 - 项目类别:
Collaborative Research and Development Grants