Bioinformatics tool development to analyze and integrate genomics data generated by high-throughput sequencing / Développement d'outils bio-info analysant les données de séquençage

高通量DNA测序（HTS）正在显著改变现代生物学，并且已经成为大多数对遗传学和分子生物学感兴趣的实验室非常重要的工具。虽然HTS技术的进步不断提高我们收集数据的能力，但越来越明显的是，将这些成果转化为科学突破的瓶颈现在在于数据挖掘和综合分析。目前还没有工具利用公开可用的表观基因组学数据集来帮助理解新的数据集。为了满足这一需求，我们建议开发基因组相关器和富集（GeCorE）工具，该工具将在超级计算机上运行，并通过网络界面供最终用户访问。这将允许非生物信息学家用户无需安装任何东西即可从该工具中受益。GeCorE将使用数千个已发布的全基因组数据集下载，并在我们的服务器上进行统一处理和组织。通过私人账户，研究所有生物体（包括许多模式生物体）的用户将能够上传他们自己的私人表观基因组学数据，并使用GeCorE应用程序对其进行表征。

High-throughput DNA sequencing (HTS) is significantly changing modern biology and is already becoming a very important tool for most laboratories interested in genetics and molecular biology. While advances in HTS technologies continue to improve our ability to collect data, it is becoming increasingly clear that the bottleneck in translating these gains into scientific breakthroughs now resides in data mining and integrative analysis. There is currently no tool exploiting the publicly available epigenomics data sets in order to help understanding new data sets. To fulfill that need, we propose to develop the Genomic Correlator and Enrichment (GeCorE) tool that will be running on a supercomputer and accessible to end users through a web interface. This will allow non-bioinformatician users to benefit from this tool without having to install anything. GeCorE will be using thousands of published whole-genome data sets downloaded, uniformly processed and organized on our server. Through private account, users working on all organisms, thus including many model organisms, will be able to upload their own private epigenomics data and use the GeCorE application to characterize them.