A Roll-to-Roll (R2R) Manufacturing Facility for High-Throughput Fabrication of Paper Digital Microfluidic Devices

用于高通量制造纸质数字微流体器件的卷对卷 (R2R) 制造设施

• 批准号: 476772-2015
• 负责人: Wheeler, Aaron
• 金额: $ 10.93万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=565390
• 关键词: Roll; R2R; Manufacturing; Facility; Throughput

We propose to develop portable microfluidic analysis tools for pre-term and post-term screening of mothers and neonates for infectious diseases (congenital rubella syndrome) and inborn disorders (fetal alcohol spectrum) in vulnerable populations in Viet Nam and Canada, respectively. These methods rely on "digital microfluidics" and the proposals leverage our recent innovation that allows for ultra-low-cost fabrication of digital microfluidic devices by inkjet printing on paper. We submit this off-cycle NSERC RTI application as part of a recently awarded 2015 E.W.R. Steacie Fellowship to assemble a custom Roll-to-Roll (R2R) manufacturing facility for high-throughput microfluidic device fabrication. The proposed work breaks into three categories: (i) analytical method development, (ii) manufacturing method development and characterization, and (iii) characterization of throughput, uniformity, and scale. For (i) we will refine the designated assays (for rubella infection surveillance and for fetal alcohol spectrum disorder screening) and implement them in the field (which requires access to thousands of validated devices). For (ii), we will assemble a slotted dye-roller deposition system to fabricate paper DMF devices, characterized by AFM, SEM, and contact angle measurements. For (iii), we will establish a rigorous quality control framework in which electrical characterization of each device is logged into bar-codes generated post-manufacture. This work will establish Canada as the international leader in high-throughput fabrication of paper digital microfluidic devices. The ultimate goal of portable, paper digital microfluidic tests for field-applications is an important one, which will contribute to improved health outcomes in Canada and around the world.

我们建议开发便携式微流控分析工具，分别在越南和加拿大的弱势群体中对母亲和新生儿进行产前和产后传染病（先天性风疹综合征）和先天性疾病（胎儿酒精谱）筛查。这些方法依赖于“数字微流体”，并且这些提议利用了我们最近的创新，该创新允许通过在纸上喷墨打印来超低成本制造数字微流体设备。我们提交此非周期NSERC RTI应用程序作为最近授予的2015年E.W.R. Steacie Fellowship将组装一个定制的卷对卷（R2R）制造设施，用于高通量微流体设备制造。拟议的工作分为三类：（i）分析方法开发，（ii）生产方法开发和表征，以及（iii）通量、均匀度和规模的表征。对于（i），我们将改进指定的检测方法（用于风疹感染监测和胎儿酒精谱系障碍筛查），并在现场实施（这需要获得数千个经过验证的设备）。对于（ii），我们将组装一个开槽的染料辊沉积系统制造纸DMF设备，其特征在于AFM，SEM和接触角测量。对于（iii），我们将建立一个严格的质量控制框架，其中每个器械的电气特性都记录在制造后生成的条形码中。这项工作将使加拿大成为高通量制造纸质数字微流体设备的国际领导者。用于现场应用的便携式纸质数字微流体测试的最终目标是一个重要目标，这将有助于改善加拿大和世界各地的健康状况。