Biological function of CREBZF and its role in the cellular stress response

CREBZF的生物学功能及其在细胞应激反应中的作用

• 批准号: 238950-2012
• 负责人: Lu, RuiRay
• 金额: $ 1.89万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=570534
• 关键词: Biological; function; CREBZF; its; role

The so-called stress response is fundamental to many normal biological processes (e.g., animal development) and pathogenesis of diseases (e.g., cancer and viral infection). My laboratory has been using Herpes Simplex Virus as a tool to study gene regulation in animal stress responses. CREBZF (or Zhangfei, ZF) is a protein that we have identified as a gene regulator inside the cells. It is believed to play a role in animal stress responses, which is mimicked by Herpes Simplex Virus in the control of viral infection cycle. The biological function of ZF, however, is still unclear. The proposed study is our continuing effort to investigate the molecular mechanisms underlying the animal stress responses and related biological processes and diseases.

所谓的应激反应是许多正常生物过程的基础（例如，动物发育）和疾病的发病机理（例如，癌症和病毒感染）。我的实验室一直在使用单纯疱疹病毒作为研究动物应激反应中基因调控的工具。CREBZF（或Zhangfei，ZF）是一种蛋白质，我们已经确定为细胞内的基因调节因子。它被认为在动物应激反应中发挥作用，这是由单纯疱疹病毒在控制病毒感染周期中模仿的。然而，ZF的生物学功能仍不清楚。该研究是我们对动物应激反应及相关生物学过程和疾病的分子机制的持续研究。