Biological function of CREBZF and its role in the cellular stress response

所谓的应激反应是许多正常生物过程(如动物发育)和疾病(如癌症和病毒感染)发病机制的基础。我的实验室一直使用单纯疱疹病毒作为研究动物应激反应中基因调控的工具。CREBZF(或张飞，ZF)是一种蛋白质，我们已经确定它是细胞内的基因调节蛋白。它被认为在动物应激反应中发挥作用，而单纯疱疹病毒在控制病毒感染周期中模仿了这种应激反应。然而，ZF的生物学功能仍不清楚。这项拟议的研究是我们继续努力研究动物应激反应的分子机制以及相关的生物学过程和疾病。

The so-called stress response is fundamental to many normal biological processes (e.g., animal development) and pathogenesis of diseases (e.g., cancer and viral infection). My laboratory has been using Herpes Simplex Virus as a tool to study gene regulation in animal stress responses. CREBZF (or Zhangfei, ZF) is a protein that we have identified as a gene regulator inside the cells. It is believed to play a role in animal stress responses, which is mimicked by Herpes Simplex Virus in the control of viral infection cycle. The biological function of ZF, however, is still unclear. The proposed study is our continuing effort to investigate the molecular mechanisms underlying the animal stress responses and related biological processes and diseases.