Germline mutations in model species and natural populations: understanding the role of the environment

模型物种和自然种群的种系突变：了解环境的作用

• 批准号: 342339-2013
• 负责人: Somers, Christopher
• 金额: $ 1.97万
• 依托单位: University of Regina
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572483
• 关键词: Germline; mutations; model; species; natural

DNA damaging agents are common in the environment, and for decades researchers have been attempting to determine whether ambient levels of environmental contaminants affect mutation rates in cells that become sperm and eggs (germline mutations). These mutations are of particular interest because they provide the raw material for natural selection, but also cause inherited abnormalities and disease. This research program examines germline mutation frequencies in model species (mice and earthworms) as well as natural populations of birds. The ultimate objective of the research is to determine the types of environmental exposures that lead to increased mutation rates, and may thereby pose a risk to individuals or populations. In addition, we seek to understand what types of mutations occur and are transmitted to subsequent generations. The outcomes will be of interest to a broad range of scientists, including geneticists, ecologists, evolutionary biologists, ecotoxicologists, and health scientists.

DNA破坏剂在环境中很常见，几十年来，研究人员一直在试图确定环境污染物水平是否会影响精子和卵子细胞的突变率（种系突变）。这些突变是特别有趣的，因为它们为自然选择提供了原料，但也会导致遗传异常和疾病。这个研究项目检查了模型物种（老鼠和蚯蚓）以及鸟类自然种群的种系突变频率。这项研究的最终目的是确定导致突变率增加的环境暴露类型，从而可能对个人或群体构成风险。此外，我们还试图了解哪些类型的突变会发生并遗传给后代。研究结果将引起广泛科学家的兴趣，包括遗传学家、生态学家、进化生物学家、生态毒理学家和健康科学家。