Development of degradable nanostructured biomaterials

可降解纳米结构生物材料的开发

• 批准号: 402611-2011
• 负责人: Oh, JungKwon
• 金额: $ 2.04万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573335
• 关键词: Development; degradable; nanostructured; biomaterials

Current nanotechnology, drawing from research in polymer chemistry, has focused on the development of multifunctional nanoscale devices that have potential for biological application. Stimuli-responsive degradation has been a method of choice for the development of novel nanomaterials. Well-defined amphiphilic block copolymers (ABPs), comprising both hydrophilic and hydrophobic blocks, have been used as building blocks to construct effective nanostructured materials through self-assembly. Polylactide (PLA) and its copolymers are biocompatible and FDA-approved for clinical use; however, one critical problem for successful biological applications of PLA-based nanomaterials is to improve the slow and uncontrolled release of encapsulated biomolecules. This research program in polymer chemistry at the biology interface focuses on the development of advanced PLA-based degradable bionanomaterials with various architectures and functionalities. These nanomaterials will be made of well-defined ABPs containing a cleavable PLA (cPLA) block that cleaves in response to external stimuli (low pH, thiols, and light) to ensure rapid, controllable release of encapsulated molecules, thus providing versatility in smart delivery. Our research results are expected to promote hydrophobic aliphatic polyesters toward widespread pharmaceutical application. Further, our research program will be expanded beyond the initial scope to address problems in other areas of polymer and materials science at the biology interface.

当前的纳米技术以高分子化学研究为基础，致力于开发具有生物应用潜力的多功能纳米器件。刺激响应降解已成为开发新型纳米材料的一种选择方法。定义良好的两亲嵌段共聚物（ABPs），包括亲水性和疏水性嵌段，已被用作通过自组装构建有效纳米结构材料的构建模块。