Motion of the charged droplets and ions in mass spectrometers

带电液滴和离子在质谱仪中的运动

• 批准号: 445591-2012
• 负责人: Ashgriz, Nasser
• 金额: $ 3.13万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=575059
• 关键词: Motion; charged; droplets; ions; mass

This proposal is aimed at improving sensitivity of mass spectrometers (MS). This will be achieved by modeling the ion flow through various parts of a MS which are responsible for ion formation and transportation. The objective is to improve the ion current in order to minimize losses and maximize quality. We will use a combination of gas flow drag and electric field to model the ionic motion. We anticipate significant improvement in the signal-to-noise ratio, thereby enabling substantially lower levels of quantization. We also anticipate development of new technologies in the mass spectrometry based on the ion motion control, using both flow and electric field. This project is in collaboration with Ionics Mass Spectrometry Group Inc. The results of this study will potentially allow Ionics to secure an industry lead positioned as the only manufacturer of a highly sensitive MS. Their customers would benefit by using much smaller samples and increasing their throughput. The public sector benefits as laboratories are able to deliver health results faster and more frequently, leading to higher quality control on ingestible consumables, such as drugs, food, beverages, and environmental protection.

该方案旨在提高质谱仪的灵敏度。这将通过对离子流通过质谱中负责离子形成和运输的各个部分进行建模来实现。目的是提高离子电流，以尽量减少损耗和提高质量。我们将使用气流阻力和电场的组合来模拟离子运动。我们预计信噪比将有显著改善，从而使量化水平大大降低。我们还预测了基于离子运动控制的质谱新技术的发展，同时使用流场和电场。