Understanding the surface properties of the drug delivery device and the oscillating positive expiratory pressure device

了解药物输送装置和振动呼气正压装置的表面特性

• 批准号: 477744-2015
• 负责人: Nie, HengYong
• 金额: $ 1.79万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579051
• 关键词: Understanding; surface; properties; drug; delivery

Trudell Medical International (TMI) is an industry leading medical device company that specializes in respiratory therapy devices. Their products improve the lives of patients with respiratory disease across Canada and internationally. TMI's respiratory therapy devices boost patient lung function. Their effective at-home treatments relieve the burdens imposed on hospitals and, in general, more easily allow sufferers to return to their lives and contribute to society. This Engage Grant looks at understanding surface properties of a drug delivery system whose efficiency is related to the retained liquid of its medication cup. Changing the wettability of the surface will allow one to reduce the retained liquid and improve the drug delivery performance of the device. In a related area, the surfaces of the Oscillating Positive Expiratory Pressure device encounter friction as the device is used. A thorough understanding of the chemistry and morphology of these surfaces will be ascertained by employing analytical techniques such as atomic force microscopy, X-ray photoelectron spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy and contact angle. Based on the results from this NSERC Engage project, we will recommend solutions to the specified wettability and friction issues and look for further collaboration with the company in order to develop technologies that benefit these medical devices. TMI is a major manufacturer of medical devices that assist people with respiratory problems and resolution of these issues will provide them with a competitive advantage and benefit their customers across Canada. Our propose project is well-defined to help improved the design of these products.

Trudell Medical International（TMI）是一家行业领先的医疗设备公司，专门从事呼吸治疗设备。他们的产品改善了加拿大和国际上呼吸系统疾病患者的生活。TMI的呼吸治疗设备可增强患者的肺功能。他们有效的家庭治疗减轻了医院的负担，一般来说，更容易让患者重返生活，为社会做出贡献。这个参与补助金着眼于了解药物输送系统的表面特性，其效率与其药物杯的保留液体有关。改变表面的润湿性将允许减少保留的液体并改善装置的药物递送性能。在相关领域，振荡呼气正压装置的表面 在使用器械时遇到摩擦。通过采用原子力显微镜、X射线光电子能谱、扫描电子显微镜、傅里叶变换红外光谱和接触角等分析技术，将彻底了解这些表面的化学和形态。 根据NSERC Engage项目的结果，我们将推荐特定润湿性和摩擦问题的解决方案，并寻求与该公司的进一步合作，以开发有利于这些医疗设备的技术。TMI是一家主要的医疗设备制造商，帮助人们解决呼吸问题，解决这些问题将为他们提供竞争优势，并使他们在加拿大的客户受益。我们提出的项目是明确的，以帮助改善这些产品的设计。