Market assessment for laser-based pathogen detection technology

基于激光的病原体检测技术的市场评估

• 批准号: 485201-2015
• 负责人: Rehse, Steven
• 金额: $ 1.02万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584792
• 关键词: Market; assessment; laser; based; pathogen

This novel technology is based on laser-induced breakdown spectroscopy (LIBS), a technique that uses a short pulse of laser light to identify bacterial pathogens based on their unique atomic composition. During the LIBS-based identification process, bacteria from fluid specimens are bombarded with intense nanosecond laser pulses that break down bacterial cells into their elemental components. The pathogen's elemental spectral fingerprint acts as a unique "bar-code" identifier which can provide an immediate classification against a pre-compiled computational model or library of pathogens. Classification of the organism based on its spectrum is mathematically calculated using multivariate analyses, known collectively as "chemometrics". Our experimental results have revealed that this spectrum is unique to the bacterial species, and even unique to the strain of the organism. The proposed technology provides pathogen identification within minutes and achieves sensitivity and specificity levels which currently exceed 95%. The detection of pathogens is of critical importance for upholding health and safety standards across multiple health-related and scientific fields, penetrating aspects of the food industry, water and environment quality control, clinical diagnostics and military-biodefense. According to a market analysis published by Markets and Markets, the North American food safety testing market is forecasted to reach $5,460 million by 2018. In 2013, North America was at the forefront of the food safety testing market. With respect to the bio-detection/defense market, Homeland Security Research Corp. projects the market value to reach $22.8 billion between 2012 and 2016. There is a clear need for pathogen detection technologies that satisfy the currently unmet needs of rapid result time, ease of use, portability and a comprehensive pathogen menu. The proposed technology has the potential to address these needs by providing easy to use, ultra-rapid (within 10 minutes) and accurate pathogen detection that can be tailored for applications requiring high-throughput and portability.

这项新技术是基于激光诱导击穿光谱(LIBS)的，这是一种根据细菌独特的原子组成使用短激光脉冲来识别细菌病原体的技术。在基于LIBS的鉴定过程中，来自液体样本的细菌被强烈的纳秒激光脉冲轰击，将细菌细胞分解成它们的基本成分。病原体的元素光谱指纹作为唯一的“条形码”识别符，可以针对预编译的计算模型或病原体资料库提供即时分类。根据光谱对生物体的分类是使用多元分析进行数学计算的，统称为“化学计量学”。我们的实验结果表明，这一光谱是细菌物种独有的，甚至是有机体菌株独有的。拟议的技术在几分钟内提供病原体识别，并达到目前超过95%的敏感性和特异性水平。 病原体的检测对于在多个与健康相关的科学领域维护健康和安全标准、渗透食品工业、水和环境质量控制、临床诊断和军事生物防御至关重要。根据Markets and Markets发布的一项市场分析，到2018年，北美食品安全检测市场预计将达到54.6亿美元。2013年，北美处于食品安全检测市场的前列。关于生物探测/防御市场，国土安全研究公司预计，2012至2016年间，该市场价值将达到228亿美元。显然需要病原体检测技术来满足目前尚未满足的快速结果时间、易用性、便携性和全面的病原体菜单的需求。拟议的技术具有满足这些需求的潜力，因为它提供了易于使用、超快速(在10分钟内)和准确的病原体检测，可以为需要高通量和便携性的应用程序量身定做。