Mechanisms of human skeletal muscle protein turnover

人体骨骼肌蛋白质周转机制

• 批准号: RGPIN-2015-04613
• 负责人: Phillips, Stuart
• 金额: $ 4.15万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589907
• 关键词: Mechanisms; human; skeletal; muscle; protein

Skeletal muscle represents the largest protein reservoir in the human body. The proteins within skeletal muscle (and other tissues) are constantly and simultaneously being synthesized and degraded. This constant protein turnover provides for an efficient mechanism for removal of damaged proteins and replacement with new proteins. In mature, post-growth, skeletal muscle a number of hormonal, nutritional, and mechanical stimuli are integrated in their regulation of the processes of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The balance between MPS and MPB is a large determinant of net muscle protein gain and thus, muscle fibre enlargement (hypertrophy) or reduction (atrophy).

骨骼肌是人体最大的蛋白质储存库。骨骼肌（和其他组织）内的蛋白质不断地同时被合成和降解。这种持续的蛋白质周转提供了一种有效的机制来去除受损的蛋白质并用新的蛋白质代替。在成熟的、生长后的骨骼肌中，许多激素、营养和机械刺激被整合在肌肉蛋白合成（MPS）和肌肉蛋白分解（MPB）过程的调节中。MPS和MPB之间的平衡是净肌肉蛋白质增加的重要决定因素，因此，肌肉纤维扩大（肥大）或减少（萎缩）。