Neural control of respiration in lampreys

七鳃鳗呼吸的神经控制

• 批准号: 217435-2013
• 负责人: Dubuc, Réjean
• 金额: $ 4.15万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593992
• 关键词: Neural; control; respiration; lampreys

Respiration is a vital motor behaviour that begins at birth and is maintained throughout life. The neural mechanisms generating and modulating respiration are still not well understood. Such an understanding requires knowledge relative to the synaptic connectivity of the entire network as well as the membrane properties of the comprising generator neurons. The complexity of the mammalian Central Nervous System (CNS) renders this task difficult and simpler CNS models are needed. Lampreys are basal vertebrates that have diverged from other vertebrate species some 560 million years ago. The organisation of their brainstem, however, is strikingly similar to that of mammals. Moreover, the neural circuitry generating respiration in lampreys stays active after isolation in vitro of their CNS, and continues to generate respiratory output very similar to that observed in intact animals. We propose to characterize the neural circuitry both at the system (synaptic connectivity) and cellular (intrinsic properties of neurons) levels in the CNS of lampreys. The relative contribution of synaptic and intrinsic properties to respiration will be established as well as the connectivity in the respiratory network.

呼吸是一种重要的运动行为，从出生时就开始了，并一直维持到一生。产生和调节呼吸的神经机制仍然不是很清楚。这样的理解需要与整个网络的突触连通性相关的知识，以及组成生成器神经元的膜特性。哺乳动物中枢神经系统(CNS)的复杂性使得这项任务变得困难，需要更简单的中枢神经系统模型。七鳃鳗是一种基本脊椎动物，大约在5.6亿年前从其他脊椎动物物种中分化出来。然而，它们脑干的组织结构与哺乳动物惊人地相似。此外，七鳃鳗在体外分离中枢神经系统后，产生呼吸的神经回路保持活跃，并继续产生与完整动物非常相似的呼吸输出。我们建议在系统(突触连接)和细胞(神经元的固有特性)两个水平上描述七鳃鳗中枢神经回路的特征。突触和固有属性对呼吸的相对贡献以及呼吸网络中的连通性将得到确立。