Regulation of ubiquitin ligase Nedd4-2 and cardiac sodium and potassium ion channels

泛素连接酶 Nedd4-2 和心脏钠钾离子通道的调节

• 批准号: 384368-2013
• 负责人: Zhang, Shetuan
• 金额: $ 2.19万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595899
• 关键词: Regulation; ubiquitin; ligase; Nedd4; cardiac

BACKGROUND: Ion channels are membrane proteins which generate electrical signals essential for cell communication. They control many vital physiological processes such as brain function and muscle contractions. The number of channels in the plasma membrane is a key determinant for the amplitude of electrical signals. The channel numbers are tightly regulated by the creation and destruction. Recent work by us and others have shown that a molecule called Nedd4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) mediates the degradation of several ion channels. Presently, it is not known how the activity of Nedd4-2 is regulated. Given its pivotal role, it is therefore critical to understand the regulation of Nedd4-2 function, which further determines the number of ion channels in the cell membrane.

背景：离子通道是一种膜蛋白，它产生细胞通讯所必需的电信号。它们控制着许多重要的生理过程，如脑功能和肌肉收缩。质膜上通道的数量是电信号振幅的关键决定因素。通道号受到创建和销毁的严格控制。我们和其他人最近的工作表明，一种名为Nedd4-2（神经前体细胞表达，发育下调4-2）的分子介导了几种离子通道的降解。目前还不清楚Nedd4-2的活性是如何被调控的。鉴于其关键作用，了解Nedd4-2功能的调控是至关重要的，它进一步决定了细胞膜中离子通道的数量。