Biomimetic Synthetic Grafts for Bone Regeneration and Epithelial Healing

用于骨再生和上皮愈合的仿生合成移植物

• 批准号: 418617-2012
• 负责人: Tamimi, Faleh
• 金额: $ 1.59万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596442
• 关键词: Biomimetic; Synthetic; Grafts; Bone; Regeneration

Millions of patients worldwide suffer from severe injuries involving skin and skeleton due to accidents, cancer, infection or birth defects. These conditions have devastating impact on the quality of life of the patients, are often life-threatening, and result in high costs to healthcare agencies. Currently, reconstruction of body parts that include skin and bone (i.e. limbs, face) has been made possible through complex surgical transplantation of living tissues from fresh cadavers. Although this technique has shown great potential, transplantation of living organs requires strong immunosuppressive therapies that reduce considerably the life expectancy of the patients. Currently there are no artificial materials designed to regenerate injuries involving both bone and skin. Dr. Tamimi's research program aims at developing synthetic materials that would eliminate the need for cadaver grafts.

全世界数百万患者因事故、癌症、感染或出生缺陷而遭受严重的皮肤和骨骼损伤。这些疾病对患者的生活质量具有破坏性影响，通常危及生命，并导致医疗机构的高成本。目前，包括皮肤和骨骼（即四肢、面部）的身体部位的重建已经通过来自新鲜尸体的活组织的复杂外科移植而成为可能。虽然这项技术已经显示出巨大的潜力，但活体器官移植需要强有力的免疫抑制疗法，这大大缩短了患者的预期寿命。目前还没有人造材料设计用于再生涉及骨骼和皮肤的损伤。塔米米博士的研究计划旨在开发合成材料，以消除对尸体移植的需要。