Micro CT image processing for high contrast images

Trikon Technologies （Montreal）专注于无损检测和3D成像，并有兴趣从工程和材料科学向生命科学扩展。生物物体的有效分析需要生物图像处理方面的特殊专业知识，因为它们的结构高度复杂，并且这些物体的性质更加微妙。该项目旨在丰富公司的投资组合，包括生物成像。**使用Trikon的先进仪器，麦吉尔大学的学术合作伙伴将分析反映生物力学要求的功能适应的小梁骨纹理。在该公司的设备中，将使用x射线断层扫描技术对一系列自然受到不同载荷条件影响的人骨进行扫描。建立并优化一系列图像处理步骤（即滤波、**分割、结构形状和拓扑分析、基于机器学习的特征提取和**量化）。这个分析序列将被统一到一个自动化协议（宏）中；通过编写宏实现处理例程的自动化对于减少员工的动手时间、优化计算处理时间和保证再现性非常重要。这项关于骨骼纹理分析的工作将作为Trikon应用专家获取专业知识的培训平台。优化和自动化图像处理协议，导致数据的定量分析将成为一个独特的**公司的能力。这种多功能表征协议的未来应用包括（但不限于）体质人类学、考古学、法医学、动物学、植物学、骨科医学和牙科，甚至是用于开发仿生材料的土木工程。Trikon专家将通过投资高端技术和数据处理来扩大他们的产业利基，这将有助于学术合作伙伴确定骨骼适应的决定因素。

Trikon Technologies (Montreal) specializes in nondestructive testing and 3D imaging, and is interested in**expansion from engineering and materials sciences towards life sciences. Effective analysis of biological**objects requires special expertise in bio-image processing because of their high structural complexity and more**delicate nature of such objects. This project aims to enrich the company's portfolio to include bio-imaging.**Using advanced instrumentation at Trikon, academic partners at McGill University will analyze trabecular**bone texture that reflects functional adaptation to biomechanical requirements. A series of human bones that**have been naturally subjected to different loading conditions will be scanned using X-ray tomography at the**company's facilities. A sequence of image processing steps will be established and optimized (i.e., filtering,**segmentation, structure shape and topology analysis, machine learning-based feature extraction and**quantification). This sequence of analysis will be unified into an automated protocol (macro); automation of**processing routines by writing macros is important in reducing hands-on time for staff, optimizing**computational processing time, and guaranteeing reproducibility. This work on bone texture analysis will**serve as a training platform for acquiring expertise by Trikon applications specialists. Optimized and**automated image processing protocols resulting in quantitative analysis of the data will become a unique**company capability. Future applications of this versatile characterization protocol include (but are not limited**to) physical anthropology, archaeology, forensics, zoology, botany, orthopaedic medicine and dentistry, and**even civil engineering for development of biomimetic materials. Trikon specialists will expand their industrial**niche by investing in high-end technology and data processing that will help to define determinants of skeletal**adaptation by the academic partner.