High toughness bioresorbable ceramics for bone regeneration
用于骨再生的高韧性生物可吸收陶瓷
基本信息
- 批准号:RGPIN-2018-05633
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Objectives of proposed research program:***High toughness materials are on the forefront of materials science due to their immense number of applications. For instance, in the biomedical field, high toughness ceramics are needed to treat bone reconstructions in maxillofacial and orthopedic applications. However, available biomaterials are either too brittle, or do not get resorb and replaced by living bone in vivo upon implantation, which are critical characteristics for optimal bone regeneration. Accordingly, the ultimate goal of this research program is to create high-toughness bone substitutes with bone-like bioresorption properties. These material will be biomimetic composites made of two bioresorbable materials: a resorbable bioceramic (i.e. brushite, monetite) and bone proteins (i.e. collagen, bone non-collagenous proteins). To achieve this goal, two main objectives will be addressed: (i) Crystals organization (ii) Proteins incorporation.***For the first objective we will study the previously unexplored option of using chiraly pure enantiomers to control crystal growth, to address the second objective we will focus on exploring the use of bone non-collagenous proteins to regulate mineral formation and collagen incorporation onto bioceramics. Summary of scientific approach:***Aim 1) Crystal organization in bioceramics***Crystal organization is critical for the high toughness properties found in naturally occurring biominerals (i.e. bone and teeth), and this is why this objective focuses on mimicking theses structure in synthetic bioceramics. During the formation of natural biominerals, direct contact with specific biomolecules regulates the nucleation, growth, morphology, organization and even function of the biominerals. Interestingly, these functional biomolecules are homochiral composed exclusively L-enantiomers of amino acids and biomolecules. We will explore the use of enantiomerically pure crystal growth inhibitors to fabricate bioceramics with organized crystallographic structure and subsequently, high toughness.***Aim 2) Bone organic ECM plays a crucial role in organizing and reinforcing bone mineral structure, and regulating its interactions with the surrounding cells. This is why bone-derived materials present much better mechanical properties and bioactivity than synthetic calcium phosphate cements. Accordingly, the second aim of the research program will focus on investigating how to incorporate bone proteins into di-calcium phosphate bioceramics to improve both the biological and the mechanical properties.
拟议研究计划的目标:* 高韧性材料由于其大量的应用而处于材料科学的前沿。例如,在生物医学领域,需要高韧性陶瓷来处理颌面和整形外科应用中的骨重建。然而,可用的生物材料要么太脆,要么在植入后不能再吸收并在体内被活骨替代,这是最佳骨再生的关键特征。因此,本研究计划的最终目标是创造具有骨样生物吸收特性的高韧性骨替代物。这些材料将是由两种生物可吸收材料制成的仿生复合材料:可吸收生物陶瓷(即透钙磷石、三斜磷钙石)和骨蛋白(即胶原、骨非胶原蛋白)。为了实现这一目标,将解决两个主要目标:(i)晶体组织(ii)蛋白质掺入。对于第一个目标,我们将研究以前未探索的选择,使用手性纯对映体来控制晶体生长,以解决第二个目标,我们将专注于探索使用骨非胶原蛋白来调节矿物质形成和胶原蛋白掺入生物陶瓷。科学方法概述:* 目标1)生物陶瓷中的晶体组织 * 晶体组织对于天然存在的生物矿物(即骨骼和牙齿)中的高韧性特性至关重要,这就是为什么本目标专注于模拟合成生物陶瓷中的这些结构。在天然生物矿物的形成过程中,与特定生物分子的直接接触调节了生物矿物的成核、生长、形态、组织甚至功能。有趣的是,这些功能性生物分子是纯手性的,仅由氨基酸和生物分子的L-对映体组成。我们将探索使用对映体纯的晶体生长抑制剂来制造具有有序晶体结构和高韧性的生物陶瓷。目的2)骨组织细胞外基质(ECM)在组织和强化骨矿物质结构以及调节骨与周围细胞的相互作用中起着重要作用。这就是为什么骨源性材料比合成磷酸钙骨水泥具有更好的机械性能和生物活性。因此,研究计划的第二个目标将集中在研究如何将骨蛋白掺入磷酸二钙生物陶瓷中,以改善生物和机械性能。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tamimi, Faleh其他文献
The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.
- DOI:
10.1186/s12903-023-03378-0 - 发表时间:
2023-09-09 - 期刊:
- 影响因子:2.9
- 作者:
Al-Maweri, Sadeq Ali;Alhajj, Mohammed Nasser;Halboub, Esam;Tamimi, Faleh;Salleh, Nosizana Mohd;Al-Ak'hali, Mohammed Sultan;Kassim, Saba;Abdulrab, Saleem;Anweigi, Lamyia;Mohammed, Marwan Mansoor Ali - 通讯作者:
Mohammed, Marwan Mansoor Ali
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis
- DOI:
10.1016/j.bone.2020.115558 - 发表时间:
2020-11-01 - 期刊:
- 影响因子:4.1
- 作者:
Tamimi, Iskandar;Cortes, Arthur Rodriguez Gonzalez;Tamimi, Faleh - 通讯作者:
Tamimi, Faleh
Regulation of enamel hardness by its crystallographic dimensions
- DOI:
10.1016/j.actbio.2012.06.002 - 发表时间:
2012-09-01 - 期刊:
- 影响因子:9.7
- 作者:
Eimar, Hazem;Ghadimi, Elnaz;Tamimi, Faleh - 通讯作者:
Tamimi, Faleh
The effect of autoclaving on the physical and biological properties of dicalcium phosphate dihydrate bioceramics: Brushite vs. monetite
- DOI:
10.1016/j.actbio.2012.04.025 - 发表时间:
2012-08-01 - 期刊:
- 影响因子:9.7
- 作者:
Tamimi, Faleh;Le Nihouannen, Damien;Barralet, Jake - 通讯作者:
Barralet, Jake
Bone regeneration in rabbit calvaria with novel monetite granules
- DOI:
10.1002/jbm.a.31842 - 发表时间:
2008-12-15 - 期刊:
- 影响因子:4.9
- 作者:
Tamimi, Faleh;Torres, Jesus;Cabarcos, Enrique Lopez - 通讯作者:
Cabarcos, Enrique Lopez
Tamimi, Faleh的其他文献
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{{ truncateString('Tamimi, Faleh', 18)}}的其他基金
High toughness bioresorbable ceramics for bone regeneration
用于骨再生的高韧性生物可吸收陶瓷
- 批准号:
RGPIN-2019-04340 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
High toughness bioresorbable ceramics for bone regeneration
用于骨再生的高韧性生物可吸收陶瓷
- 批准号:
RGPIN-2019-04340 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
High toughness bioresorbable ceramics for bone regeneration
用于骨再生的高韧性生物可吸收陶瓷
- 批准号:
RGPIN-2019-04340 - 财政年份:2019
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Micro CT image processing for high contrast images
高对比度图像的显微 CT 图像处理
- 批准号:
523215-2018 - 财政年份:2018
- 资助金额:
$ 2.04万 - 项目类别:
Engage Grants Program
Biomimetic Synthetic Grafts for Bone Regeneration and Epithelial Healing
用于骨再生和上皮愈合的仿生合成移植物
- 批准号:
418617-2012 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Biomimetic Synthetic Grafts for Bone Regeneration and Epithelial Healing
用于骨再生和上皮愈合的仿生合成移植物
- 批准号:
418617-2012 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Laser-sintered dentures engineered for optimal performance
激光烧结假牙专为实现最佳性能而设计
- 批准号:
469834-2014 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Research and Development Grants
Accuracy of CAD/CAM Dental Models
CAD/CAM 牙科模型的准确性
- 批准号:
508094-2016 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Engage Grants Program
Laser-sintered dentures engineered for optimal performance
激光烧结假牙专为实现最佳性能而设计
- 批准号:
469834-2014 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Collaborative Research and Development Grants
Biomimetic Synthetic Grafts for Bone Regeneration and Epithelial Healing
用于骨再生和上皮愈合的仿生合成移植物
- 批准号:
418617-2012 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
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