Development of design tools for optimizing the shell formulation of soft gel capsules

源自天然来源的聚合物在医疗和个人护理应用中具有显着的优势，因为它们可以代谢成安全的副产品。然而，用于从各种天然来源中分离此类聚合物的提取过程会导致聚合物性能的显着差异，无论是在供应商之间，还是同一供应商的批次之间。这种可变性给制造可重复产品带来了挑战，特别是考虑到监管压力，对于生物医学材料来说更成问题。该项目的工业合作伙伴 Accucaps 开发了一种用于封装活性剂的软胶囊工艺，该工艺已应用于多个领域，包括药品、营养品、化妆品等。软凝胶组合物基于明胶，一种天然聚合物

Polymers derived from natural sources offer significant advantages in medical and personal care applications given that they can be metabolized into safe by-products. However, the extraction processes used to isolate such polymers from various natural sources result in significant variation in polymer properties, both between suppliers or even batch-to-batch from the same supplier. This variability creates challenges with manufacturing reproducible products, particularly problematic for biomedical materials given regulatory pressures. The industrial partner of this project, Accucaps, has developed a process to create soft gel capsules for encapsulating active agents that is being applied across multiple fields, including pharmaceuticals, nutraceuticals, cosmetics, and others. The soft gel compositions are based on gelatin, a natural polymer