Laboratory for the Development and Application of Advanced Functional Polymeric Materials

先进功能高分子材料开发与应用实验室

• 批准号: RGPIN-2015-06282
• 负责人: Serpe, Michael
• 金额: $ 4.3万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=614054
• 关键词: Laboratory; Development; Application; Advanced; Functional

The research proposed in this DG is aimed at developing novel materials that can be used to solve human health and environmental problems. To accomplish this, we will develop new technologies capable of: 1) detecting molecular indicators of disease; 2) delivering small molecule therapeutics to systems in a controlled and triggered fashion; 3) lifting weights and actuating in response to environmental triggers; 4) removing organic and heavy metal contaminants from contaminated water using fibers from renewable resources. These technologies will be developed by modification of the chemistry of polymers and polymer-based systems to yield a given function. Specifically, the group has developed layered materials made of poly (N-isopropylacrylamide) hydrogel particles (microgels) that exhibit visual color. Beginning in 2009, we have modified this technology such that it can be used to detect small DNA sequences. In one example, part of the work proposed in this DG will focus on new ways to detect DNA, allowing long (100 bases long) DNA to be detected. This will be important for achieving point 1 above. We also showed that the same technology could be used to control the release and delivery of small molecules to various systems. In this DG, we will further develop the technology to gain finer control of the delivery characteristics, moving to the point where these devices can be coated onto medical devices, which can release therapeutic drugs capable of preventing infections induced by implants and implantation procedures. Finally, our materials can be used as artificial muscles and actuators that are triggered in response to external stimuli. Our muscles are stronger pound-for-pound than humans. This DG will focus on turning this technology into devices that actuate in response electric, magnetic, and electromagnetic (light) fields. These devices will also be used to deliver small molecule therapeutic drugs to a variety of systems (including biological), among other things. The group's efforts will also focus on further developing our polymer-based technologies for removing small molecule and heavy metal contaminants from water (i.e., water remediation). For this DG, we will focus our efforts on developing polymer-based materials made from fibers obtained from renewable resources. A comprehensive study of the recyclability and reusability of the materials will also be undertaken. Multiple other avenues of research will be pursued with the DG funds requested here. For example, our polymer-based actuators will be modified such that they can be used for detecting molecules of interest. Furthermore, electrical properties of our layered materials will be investigated, and correlated with the concentration of a molecule of interest. In another example, we will develop novel microgels that can be used for diagnosing skin cancer. All projects are focused on solving health and environmental problems.

本DG中提出的研究旨在开发可用于解决人类健康和环境问题的新型材料。为了实现这一目标，我们将开发新技术，能够：1）检测疾病的分子指标; 2）以受控和触发的方式向系统提供小分子治疗剂; 3）举重和响应环境触发器; 4）使用可再生资源的纤维从污染水中去除有机和重金属污染物。这些技术将通过修改聚合物和聚合物基系统的化学性质来开发，以产生给定的功能。具体来说，该小组已经开发出由聚（N-异丙基丙烯酰胺）水凝胶颗粒（微凝胶）制成的层状材料，这些材料显示出视觉颜色。从2009年开始，我们对这项技术进行了修改，使其可以用于检测小DNA序列。在一个例子中，本DG中提出的部分工作将集中在检测DNA的新方法上，允许检测长（100个碱基长）DNA。这对实现上述第1点很重要。我们还表明，同样的技术可以用于控制小分子向各种系统的释放和递送。在本DG中，我们将进一步开发技术，以更好地控制输送特性，使这些设备可以被涂覆到医疗设备上，从而可以释放能够预防植入物和植入程序引起的感染的治疗药物。最后，我们的材料可以用作人造肌肉和执行器，可以响应外部刺激而触发。我们的肌肉每磅都比人类强壮。该DG将专注于将该技术转化为响应电场，磁场和电磁（光）场的设备。这些设备还将用于将小分子治疗药物输送到各种系统（包括生物系统）等。该集团的努力还将集中在进一步开发我们的聚合物为基础的技术，以消除小分子和重金属污染物从水中（即，水污染治理）。对于该DG，我们将集中精力开发由可再生资源获得的纤维制成的聚合物基材料。还将对这些材料的可回收性和可再利用性进行全面研究。将利用此处所要求的总干事资金寻求多种其他研究途径。例如，我们的基于聚合物的致动器将被修改，使得它们可以用于检测感兴趣的分子。此外，我们的层状材料的电性能将被研究，并与感兴趣的分子的浓度相关。在另一个例子中，我们将开发可用于诊断皮肤癌的新型微凝胶。所有项目都侧重于解决健康和环境问题。