Mechanical mechanisms of inflammatory cell attraction to myofibroblasts in collagen matrix - implications for lung fibrosis

胶原基质中炎症细胞吸引肌成纤维细胞的机械机制——对肺纤维化的影响

• 批准号: 357572
• 负责人: Hinz Boris
• 金额: $ 52.39万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2021-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=357572&lang=en
• 关键词: Fibrosis; Myofibroblasts; Wound Healing

Different cells are activated to rapidly repair injured tissues. These cells are called myofibroblasts because they secrete fibrous collagen matrix ("fibro") that is contracted ("myo") into mechanically stabilizing scar tissue. Myofibroblasts deregulation

不同的细胞被激活，以快速修复受损组织。这些细胞被称为肌成纤维细胞，因为它们分泌纤维状的胶原基质(纤维)，收缩(肌肉)形成机械稳定的瘢痕组织。肌成纤维细胞放松调控