Injectable bioactive hydrogel for the regeneration of intervertebral disc

用于椎间盘再生的可注射生物活性水凝胶

• 批准号: 508365-2017
• 负责人: Lerouge, Sophie
• 金额: $ 6.61万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621895
• 关键词: Injectable; bioactive; hydrogel; regeneration; intervertebral

Intervertebral discs allow slight movement of the vertebrae and play an important role inshock absorption in the spine but can be damaged with time. Disc degeneration is one of theleading causes of low back pain, which affects a large proportion of the global population at ahuge socioeconomic burden. It is so common that approximately 1 in 50 Canadians becomedisabled by back pain.When drugs or physical therapy are not sufficient, surgery is the only offered option whichconsists in the removal of the disc and/or its replacement by an implant. There is a clear needfor minimally invasive repair of the intervertebral disc to avoid surgical treatment and longterm complications which affect patients after simple removal of the disc.The project aims to provide a minimally invasive treatment for damaged intervertebral discsbased on the use of a material which can be injected into the disk through a needle andrapidly solidify. This material is combined with cells and bioactive products that can activelypromote the reparation of the tissue, in order to better restore its mechanical properties andits normal composition. This injectable product should also have potential for the repair ofcartilage, which affects an even higher number of patients.Two Canadians companies are strongly interested in this product. Therefore, in addition to theimprovement of the health of Canadians, this project will help reinforce the quite recentCanadian industry in this strategic field

椎间盘允许椎骨轻微运动，在脊柱的减震中发挥重要作用，但随着时间的推移会受损。椎间盘退变是导致腰痛的主要原因之一，它影响了全球很大一部分人口，造成了巨大的社会经济负担。这是如此普遍，大约有1在50加拿大人成为残疾的背部疼痛。当药物或物理治疗是不够的，手术是唯一提供的选择，其中包括在椎间盘切除和/或其替代植入物。为了避免手术治疗和单纯摘除椎间盘后影响患者的长期并发症，明确需要微创修复椎间盘。该项目旨在为受损椎间盘提供一种微创治疗方法，该方法基于使用一种可通过针注入椎间盘并迅速固化的材料。这种材料与细胞和生物活性产品相结合，可以积极促进组织的修复，以便更好地恢复其机械性能和正常组成。这种可注射的产品也应该有修复软骨的潜力，这影响了更多的患者。两家加拿大公司对这种产品非常感兴趣。因此，除了改善加拿大人的健康状况外，该项目还将有助于加强加拿大在这一战略领域的最新产业