Injectable bioactive hydrogel for the regeneration of intervertebral disc

用于椎间盘再生的可注射生物活性水凝胶

• 批准号: 508365-2017
• 负责人: Lerouge, Sophie
• 金额: $ 15.13万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657248
• 关键词: Injectable; bioactive; hydrogel; regeneration; intervertebral

Intervertebral discs allow slight movement of the vertebrae and play an important role in**shock absorption in the spine but can be damaged with time. Disc degeneration is one of the**leading causes of low back pain, which affects a large proportion of the global population at a**huge socioeconomic burden. It is so common that approximately 1 in 50 Canadians become**disabled by back pain.**When drugs or physical therapy are not sufficient, surgery is the only offered option which**consists in the removal of the disc and/or its replacement by an implant. There is a clear need**for minimally invasive repair of the intervertebral disc to avoid surgical treatment and long**term complications which affect patients after simple removal of the disc.**The project aims to provide a minimally invasive treatment for damaged intervertebral discs**based on the use of a material which can be injected into the disk through a needle and**rapidly solidify. This material is combined with cells and bioactive products that can actively**promote the reparation of the tissue, in order to better restore its mechanical properties and**its normal composition. This injectable product should also have potential for the repair of**cartilage, which affects an even higher number of patients.**Two Canadians companies are strongly interested in this product. Therefore, in addition to the**improvement of the health of Canadians, this project will help reinforce the quite recent**Canadian industry in this strategic field

椎间盘允许椎骨的轻微运动，在脊柱的减震中起着重要作用，但随着时间的推移，椎间盘会受到损伤。椎间盘退变是导致腰痛的主要原因之一，影响了全球很大一部分人口，造成了巨大的社会经济负担。背痛非常普遍，大约每50个加拿大人中就有1人因背痛而残疾。当药物或物理治疗不够时，手术是唯一的选择，手术包括取出椎间盘和/或用植入物代替。显然需要微创修复椎间盘，以避免手术治疗和简单的椎间盘取出后影响患者的长期并发症。**该项目旨在为受损椎间盘**提供一种微创治疗方法，该方法使用一种材料，可以通过针头注入椎间盘并**快速固化。这种材料结合了细胞和生物活性产品，可以主动促进组织的修复，以便更好地恢复其机械性能和正常成分。这种注射产品也应该有修复软骨的潜力，这影响到更多的患者。**两家加拿大公司对这种产品非常感兴趣。因此，除了**提高加拿大人的健康水平外，该项目还将有助于加强**加拿大最近在这一战略领域的工业