Injectable thermosensitive hydrogels with enhanced mechanical properties for cell therapy

用于细胞治疗的具有增强机械性能的可注射热敏水凝胶

• 批准号: RGPIN-2015-05169
• 负责人: Lerouge, Sophie
• 金额: $ 2.55万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638074
• 关键词: Injectable; thermosensitive; hydrogels; enhanced; mechanical

Injectable hydrogels are increasingly used for minimally invasive treatment of diseases, especially in combination with cell seeding, because they can ensure appropriate cell localization, retention and survival. Ideally, an injectable gel should have relatively low viscosity before and during injection but gel rapidly and exhibit high mechanical strength after being delivered, to ensure matrix cohesion and tolerance to in vivo stresses. However, there is a lack of injectable material that combines these qualities with excellent cell compatibility. Our team recently developed a method for preparing high-strength, fast-thermogelling chitosan (CH)-based hydrogels using new gelation agents that may solve this issue.

可注射水凝胶越来越多地用于微创治疗疾病，特别是与细胞播种相结合，因为它们可以确保适当的细胞定位、保留和存活。理想情况下，可注射凝胶在注射前和注射过程中应具有相对较低的粘度，但在输送后应迅速凝胶化并具有较高的机械强度，以确保基质内聚性和对体内应力的耐受性。然而，缺乏将这些特性与优异的细胞相容性结合起来的可注射材料。我们的团队最近开发了一种使用新型凝胶剂制备高强度、快速热凝胶壳聚糖（CH）基水凝胶的方法，可能会解决这个问题。