Spatial organization of T cell signalling

T 细胞信号传导的空间组织

• 批准号: nhmrc : GNT1059278
• 负责人: Prof Katharina Gaus
• 金额: $ 60.14万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/spatial-organization-t-cell-signalling/1344686
• 关键词: Spatial; organization; cell; signalling

The regulation to early T cell signalling is a critical step in immune responses. Superimposed onto the biochemical pathways is a spatial organization that defines the immunological synapse. My research aims to map the principles of the spatial organization on the molecular scale to identify how lipids could unbalance the dynamic signalling equilibrium, for example in obese patients. To achieve this goal, my research group has developed single molecule microscopy approaches.

对早期T细胞信号传导的调节是免疫应答中的关键步骤。叠加在生物化学途径上的是一种空间组织，它定义了免疫突触。我的研究旨在绘制分子尺度上的空间组织原则，以确定脂质如何使动态信号平衡失衡，例如在肥胖患者中。为了实现这一目标，我的研究小组开发了单分子显微镜方法。