Mechanisms of epigenetic conversions in S.cerevisiae

酿酒酵母表观遗传转化机制

• 批准号: RGPIN-2015-06727
• 负责人: Yankulov, Krassimir
• 金额: $ 3.28万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628922
• 关键词: Mechanisms; epigenetic; conversions; S.cerevisiae

Eukaryotic genomes are packaged in a high-order complex called chromatin. Besides its obvious structural role, chromatin also plays a critical role in the regulation of gene expression. Depending on its level of condensation, chromatin can allow or prevent the access of transcription factors to their target genes. Importantly, such restrictive or permissive chromatin structures are heritable through multiple cell generations. Hence, heritable chromatin structures ensure the continuity of gene expression programs in the progeny. These chromatin transactions are the focus of the specialised field of epigenetics.

真核生物的基因组被包装在一个叫做染色质的高级复合体中。除了其明显的结构作用外，染色质在基因表达调控中也起着关键作用。根据其凝聚水平，染色质可以允许或阻止转录因子接近其靶基因。重要的是，这种限制性或允许性染色质结构可通过多代细胞遗传。因此，可遗传的染色质结构确保了后代中基因表达程序的连续性。这些染色质交易是表观遗传学专业领域的焦点。