Canid herpesvirus 1 replication

犬疱疹病毒1型(CHV-1)是引起犬呼吸道和生殖器感染的重要兽医病原体。在小狗身上，它可以导致全身性感染和死亡。在成年狗身上，该病毒与眼部和呼吸系统疾病有关。它还与不孕不育和堕胎有关。治疗选择有限。CHV-1是水痘病毒属的成员。它只感染狗和类似狗的动物，如狼、郊狼、狐狸和狼。尽管这种病原体在兽医中很重要，但人们对CHV-1的生物学知之甚少。这项研究计划的目的是了解CHV-1感染的分子和细胞生物学。我们将针对CHV-1感染的两个关键方面：1)病毒如何进入高度专业化的极化细胞并在其中传播，例如在呼吸道中发现的细胞。这些细胞有两个功能截然不同的两边，以及控制哪些分子最终流向哪一边的机制。2)我们还将研究是什么控制了病毒基因的开启和关闭。所产生的结果将对那些已承诺将CHV-1用作狗特有治疗方法的媒介的人特别感兴趣。产生的信息应该揭示CHV-1感染的关键方面，CHV-1是一种研究不足的兽医病原体。它还可能产生关于极化上皮细胞感染和病毒基因表达策略的新的基础知识。

Canid herpesvirus 1 (CHV-1) is an important veterinary pathogen that causes respiratory and genital infections in dogs. In puppies, it can lead to a generalized infection and death. In adult dogs, the virus is associated with ocular and respiratory disease. It has also been associated with infertility and abortions. There are limited treatment options. CHV-1 is a member of the genus Varicellovirus. It only infects dogs and dog-like animals such as wolves, coyotes, foxes and jackals. Despite the importance of this pathogen in veterinary medicine, very little is known about the biology of CHV-1. The objective of this research program is to understand the molecular and cellular biology of CHV-1 infection. We will target two critical aspects of CHV-1 infection: 1) How the virus enters and traffics within highly specialized polarized cells such as those found in the respiratory track. These cells have two sides with very different functions, and mechanisms in place that govern which molecules ultimately go to which side. 2) We will also study what controls how viral genes are turned on and off. The results generated will be of particular interest to those who have undertaken to use CHV-1 as a vector for dog-specific therapeutic approaches. The information generated should reveal critical aspects of CHV-1 infection, an understudied veterinary pathogen. It will also likely generate new fundamental knowledge regarding the infection of polarized epithelial cells and strategies of viral gene expression.