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Canid herpesvirus 1 replication

犬疱疹病毒1型复制

基本信息

批准号：
RGPIN-2016-06475
负责人：
Pearson, Angela
金额：
$ 2.4万
依托单位：
Institut national de la recherche scientifique
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2020
资助国家：
加拿大
起止时间：
2020-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=710304
关键词：
Canid herpesvirus replication

项目摘要

Canid herpesvirus 1 (CHV-1) is an important veterinary pathogen that causes respiratory and genital infections in dogs. In puppies, it can lead to a generalized infection and death. In adult dogs, the virus is associated with ocular and respiratory disease. It has also been associated with infertility and abortions. There are limited treatment options. CHV-1 is a member of the genus Varicellovirus. It only infects dogs and dog-like animals such as wolves, coyotes, foxes and jackals. Despite the importance of this pathogen in veterinary medicine, very little is known about the biology of CHV-1. The objective of this research program is to understand the molecular and cellular biology of CHV-1 infection. We will target two critical aspects of CHV-1 infection: 1) How the virus enters and traffics within highly specialized polarized cells such as those found in the respiratory track. These cells have two sides with very different functions, and mechanisms in place that govern which molecules ultimately go to which side. 2) We will also study what controls how viral genes are turned on and off. The results generated will be of particular interest to those who have undertaken to use CHV-1 as a vector for dog-specific therapeutic approaches. The information generated should reveal critical aspects of CHV-1 infection, an understudied veterinary pathogen. It will also likely generate new fundamental knowledge regarding the infection of polarized epithelial cells and strategies of viral gene expression.

犬疱疹病毒1型（CHV-1）是引起犬呼吸道和生殖道感染的重要兽医病原体。在幼犬中，它可能导致全身感染和死亡。在成年狗中，该病毒与眼部和呼吸道疾病有关。它也与不孕症和堕胎有关。治疗选择有限。 CHV-1是水痘病毒属的成员。它只感染狗和狗一样的动物，如狼，郊狼，狐狸和豺狼。尽管这种病原体在兽医学中很重要，但对CHV-1的生物学知之甚少。本研究计划的目的是了解CHV-1感染的分子和细胞生物学。我们将针对CHV-1感染的两个关键方面：1）病毒如何进入高度专业化的极化细胞（如呼吸道中发现的细胞）并在其中传播。这些细胞有两个功能非常不同的侧面，以及控制哪些分子最终到达哪一侧的机制。 2)我们还将研究是什么控制着病毒基因的开启和关闭。产生的结果将是特别感兴趣的那些谁承担使用CHV-1作为载体的狗特异性治疗方法。所产生的信息应揭示CHV-1感染的关键方面，这是一种研究不足的兽医病原体。它还可能产生关于极化上皮细胞感染和病毒基因表达策略的新的基础知识。