Canid herpesvirus 1 replication

犬疱疹病毒1型（CHV-1）是一种重要的兽医病原体，可引起犬呼吸道和生殖器感染。在幼犬中，它会导致全身性感染和死亡。在成年犬中，该病毒与眼部和呼吸道疾病有关。它还与不孕和流产有关。治疗方案有限。CHV-1是水痘病毒属的一种。它只感染狗和类狗动物，如狼、土狼、狐狸和胡狼。尽管这种病原体在兽医学中很重要，但对CHV-1的生物学知之甚少。本研究计划的目的是了解CHV-1感染的分子和细胞生物学。我们将针对CHV-1感染的两个关键方面：1)病毒如何进入和运输高度特化的极化细胞，例如在呼吸道中发现的细胞。这些细胞有两面，它们的功能非常不同，也有相应的机制来决定哪些分子最终会流向哪一面。我们还将研究是什么控制着病毒基因的开启和关闭。所产生的结果将对那些已承诺使用CHV-1作为犬特异性治疗方法载体的人特别感兴趣。所产生的信息应揭示CHV-1感染的关键方面，这是一种尚未得到充分研究的兽医病原体。它还可能产生关于极化上皮细胞感染和病毒基因表达策略的新的基础知识。*****

Canid herpesvirus 1 (CHV-1) is an important veterinary pathogen that causes respiratory and genital infections in dogs. In puppies, it can lead to a generalized infection and death. In adult dogs, the virus is associated with ocular and respiratory disease. It has also been associated with infertility and abortions. There are limited treatment options. CHV-1 is a member of the genus Varicellovirus. It only infects dogs and dog-like animals such as wolves, coyotes, foxes and jackals. Despite the importance of this pathogen in veterinary medicine, very little is known about the biology of CHV-1. The objective of this research program is to understand the molecular and cellular biology of CHV-1 infection. We will target two critical aspects of CHV-1 infection: 1) How the virus enters and traffics within highly specialized polarized cells such as those found in the respiratory track. These cells have two sides with very different functions, and mechanisms in place that govern which molecules ultimately go to which side. 2) We will also study what controls how viral genes are turned on and off. The results generated will be of particular interest to those who have undertaken to use CHV-1 as a vector for dog-specific therapeutic approaches. The information generated should reveal critical aspects of CHV-1 infection, an understudied veterinary pathogen. It will also likely generate new fundamental knowledge regarding the infection of polarized epithelial cells and strategies of viral gene expression.*****