Structural and Functional Studies of the Regulatory Mechanism of Ubiquitin Enzymes in Stress Response and Gene Expression

泛素酶在应激反应和基因表达中的调节机制的结构和功能研究

• 批准号: RGPIN-2017-06520
• 负责人: Tong, Yufeng
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629937
• 关键词: Structural; Functional; Studies; Regulatory; Mechanism

Cells have sophisticated mechanisms to respond to changes in the physiological conditions they live in, such as oxygen or nutrient deprivation or over-supply, imbalances of electrolytes, and deviation from normal body temperatures. To maximize survival under these stresses, cells use different molecular mechanisms to adjust their internal biological processes. In rapid defences, the proteins that carry out cellular functions are modified at certain residues to switch their conformation and interaction partners so that they are activated, deactivated, or tagged for degradation. Over a longer time scale, the expression profile of genes is fundamentally altered to adapt the cells to a changed environment.

细胞有复杂的机制来对它们所处的生理条件的变化做出反应，例如氧气或营养缺乏或供应过剩，电解质失衡，以及偏离正常体温。为了最大限度地在这些压力下存活，细胞使用不同的分子机制来调整其内部生物过程。在快速防御中，执行细胞功能的蛋白质在某些残基被修饰以改变其构象和相互作用伙伴，从而使它们被激活、失活或标记为降解。在更长的时间尺度上，基因的表达谱从根本上改变了，以使细胞适应变化的环境。