An integrative approach to stress physiology in fish

鱼类应激生理学的综合方法

• 批准号: RGPIN-2017-05487
• 负责人: Gilmour, Kathleen
• 金额: $ 4.23万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630899
• 关键词: integrative; approach; stress; physiology; fish

The long-term objective of my research program is to understand the physiology of stress in fish. Most animals, including fish, regularly face environmental challenges that threaten their homeostasis. The initiation of a coordinated suite of behavioural, neuroendocrine and cellular events, collectively termed a stress response, allows the animal to respond to such stressors. Despite the importance of stress responses to the survival and fitness of individuals and populations, our knowledge of how they are regulated and integrated with other physiological systems remains limited, particularly during chronic stress. Moreover, the field of stress physiology is becoming more complex as evidence accrues for early life adversity and intergenerational effects of stress in shaping the stress physiology and behaviour of the next generation.

我的研究计划的长期目标是了解鱼类的应激生理学。大多数动物，包括鱼类，经常面临威胁其体内平衡的环境挑战。一套协调的行为，神经内分泌和细胞事件的启动，统称为应激反应，允许动物对这种应激源作出反应。尽管压力反应对个体和群体的生存和健康至关重要，但我们对它们如何被调节并与其他生理系统整合的知识仍然有限，特别是在慢性压力期间。此外，压力生理学领域正变得越来越复杂，因为越来越多的证据表明，早期生活逆境和压力的代际影响会影响下一代的压力生理学和行为。