Differentiation of memory operations along the hippocampal long axis

沿海马长轴的记忆操作分化

• 批准号: RGPIN-2015-03637
• 负责人: Poppenk, Jordan
• 金额: $ 2.4万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631230
• 关键词: Differentiation; memory; operations; along; hippocampal

Here I propose a cognitive neuroscience research program concerned with the distinct contributions of anterior hippocampus (aHPC) and posterior hippocampus (pHPC) to human cognition. The hippocampus is a brain structure with known importance for long-term memory, navigation, and other functions in humans and animals. In spite of its central importance in cognition, it is not known why, while internal circuitry of the hippocampus is organized in a similar fashion from front to back, only damage to pHPC impacts performance in most memory tests. In part because of this resistance to memory loss, intractable epileptic seizures, in which the hippocampus is implicated, are sometimes treated by removing aHPC but preserving much of pHPC.

在这里，我提出了一个认知神经科学的研究计划，前海马（aHPC）和后海马（pHPC）对人类认知的不同贡献。海马体是一种大脑结构，对人类和动物的长期记忆、导航和其他功能具有重要意义。尽管pHPC在认知中具有核心重要性，但尚不清楚为什么海马体的内部电路从前到后以类似的方式组织，只有pHPC的损伤才会影响大多数记忆测试中的表现。部分由于这种对记忆丧失的抵抗力，涉及海马的顽固性癫痫发作有时通过去除aHPC但保留大部分pHPC来治疗。