CHEMICAL SCREENING AND OPTIMIZATION FACILITY (CSOF) - CHEMICAL OPTIMIZATION APPROACHES

尤尼斯·肯尼迪·施莱佛国家研究所避孕研究分支 儿童健康和人类发展部（NICHD）支持开发化合物的研究， 可破坏卵子发生、精子发生、正常排卵、精子成熟和/或功能 提供可供男子和/或妇女使用的安全有效的避孕药具。的 化学筛选和优化设施（CSOF）旨在通过识别，优化和进行小规模生产分子试剂来实现独特的作用， 避孕效果。CSOF提供全面的项目管理和能力，以支持这些目标，根据新的避孕方法的发展：这些包括，但不限于，重组肽和蛋白质的产生，测定开发，高通量筛选（HTS），X射线晶体学，计算化学，药物化学和药理学。将根据非药品生产质量管理规范（非GMP）制备CSOF鉴定和优化的化合物，以进行进一步的临床前评价。CSOF在CRB的药物开发使命中发挥着关键作用。

The Contraception Research Branch (CRB) within the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) supports research to develop compounds that can disrupt oogenesis, spermatogenesis, normal ovulation, sperm maturation and/or function affording safe and effective contraceptives that can be implemented for men and/or women. The Chemical Screening and Optimization Facility (CSOF) is designed to fulfill a unique role by identifying, optimizing, and conducting small scale production of molecular agents that achieve a contraceptive effect. The CSOF provides overall project management and the capabilities to support these objectives pursuant to development of new contraceptive methods: these include, but are not limited to, the generation of recombinant peptides and proteins, assay development, high throughput screening (HTS), x-ray crystallography, computational chemistry, medicinal chemistry, and pharmacology. Compounds identified and optimized by the CSOF will be prepared under non-Good Manufacturing Practices (non-GMP) for further preclinical evaluation. The CSOF plays a critical role in the drug development mission of the CRB.