Tackling physics challenges of conformal small animal image guided radiotherapy

应对适形小动物图像引导放射治疗的物理挑战

• 批准号: RGPIN-2016-04055
• 负责人: Bazalova, Magdalena
• 金额: $ 2.33万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633322
• 关键词: Tackling; physics; challenges; conformal; small

Functionalized nanoparticles have shown promise as a suitable cancer imaging contrast agent as well as therapeutic agent. However, the potential for nanoparticle use in combination with radiotherapy has not been fully examined and has been primarily investigated by means of cancer cell studies. Cell studies have demonstrated that radiation delivered in the presence of nanoparticles was more effective in killing cancer cells than radiotherapy alone. While this important finding could potentially result in improved treatment outcomes with reduced side effects, before radiotherapy with nanoparticles can be considered for clinical trials, its effects in small animals must first be investigated.

功能化的纳米颗粒已经显示出作为合适的癌症成像造影剂以及治疗剂的前景。然而，纳米粒子与放射治疗联合使用的潜力尚未得到充分研究，主要通过癌细胞研究进行了研究。细胞研究表明，在纳米粒子存在下递送的辐射比单独的放射疗法更有效地杀死癌细胞。虽然这一重要发现可能会改善治疗效果，减少副作用，但在考虑将纳米粒子放射治疗用于临床试验之前，必须首先研究其在小动物中的作用。