Spatiotemporal models of intra and extra cellular processes

细胞内和细胞外过程的时空模型

• 批准号: RGPIN-2016-04314
• 负责人: Iron, David
• 金额: $ 1.09万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=635642
• 关键词: Spatiotemporal; models; intra; extra; cellular

Mathematical models are playing an increasingly important role in the understanding of biological processes. My research focuses on models related to cellular processes. Specifically I use methods from asymptotic analysis and perturbation theory to study systems which form localized structures. Such systems play important roles in many areas of biology. The new models being considered include a model of plaque formation in atherosclerosis, a model of the formation of polarity in the early C. elegans development and a model of cell surface receptor aggregation. As well we will continue to work on models of cell signal transduction and general pattern formation. Some details of each project follow.

数学模型在理解生物过程中起着越来越重要的作用。我的研究重点是与细胞过程相关的模型。具体来说，我使用的方法从渐近分析和微扰理论研究系统，形成本地化的结构。这些系统在生物学的许多领域发挥着重要作用。正在考虑的新模型包括动脉粥样硬化斑块形成模型，早期C. elegans发育和细胞表面受体聚集的模型。我们也将继续研究细胞信号转导和一般模式形成的模型。 每个项目的一些细节如下。