Development of an inexpensive paper spray mass spectrometry screening assay for fentanyl and other opioid analogs

开发一种廉价的纸喷雾质谱筛选方法来检测芬太尼和其他阿片类药物类似物

• 批准号: 516557-2017
• 负责人: Gill, Christopher
• 金额: $ 1.82万
• 依托单位: Vancouver Island University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640461
• 关键词: Development; inexpensive; paper; spray; mass

The aim of this project is to develop a low cost rapid screening assay suitable for the detection andidentification of opioid and other drug analogs (e.g. fentanyl and its derivatives) in complex samples. Theresearch is specifically targeted at developing a new technology for implementation in harm reductionstrategies, in order to reduce loss of life from dangerous drug cocktails that are increasingly common in streetdrugs. The technique of paper spray mass spectrometry will be employed, whereby small paper strips serve asboth the sampling device and the platform for introducing the sample directly to a mass spectrometer. Thisdirect mass spectrometry approach removes the need for complex sample handling, and provides definitive andquantitative chemical information for small samples in approximately one minute. LifeLabs is an excellentpartner for this project, and their commitment to improving drug screening approaches in British Columbia(and Canada) will ensure the rapid future development and implementation of our research.

本项目的目的是开发一种低成本的快速筛选方法，适用于复杂样品中阿片类药物和其他药物类似物（如芬太尼及其衍生物）的检测和鉴定。这项研究专门针对开发一种新技术，用于实施减少伤害的战略，以减少在街头毒品中越来越常见的危险药物鸡尾酒造成的生命损失。将采用纸喷雾质谱技术，其中小纸条既作为采样装置又作为将样品直接引入质谱仪的平台。这种直接的质谱分析方法消除了复杂的样品处理的需要，并在大约一分钟内为小样品提供明确和定量的化学信息。LifeLabs是该项目的优秀合作伙伴，他们致力于改善不列颠哥伦比亚省（和加拿大）的药物筛选方法，将确保我们的研究在未来快速发展和实施。