Electrophysiological recording equipment for the study of neural networks during memory formation

用于研究记忆形成过程中神经网络的电生理记录设备

• 批准号: RTI-2018-00375
• 负责人: Spencer, Gaynor
• 金额: $ 3.68万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642162
• 关键词: Electrophysiological; recording; equipment; study; neural

The equipment I am requesting is for an electrophysiological recording rig. The electrophysiological recordings we perform are electrical recordings from brain cells, which are used to measure the activity levels of cells, the flow of electrical current through specific membrane ion channels, and to measure the communication between different brain cells in a neural network. The research we are conducting aims to determine the role of the Vitamin A metabolite, retinoic acid, on memory formation. Blocking retinoic acid signaling pathways impedes memory formation in species from molluscs to humans. However, very little is known about how retinoic acid affects synaptic connections within networks of the brain. The equipment I have requested is essential recording equipment required to upgrade an electrophysiological recording rig to allow me to continue with my NSERC-funded research. A large component of my NSERC research is to investigate how retinoic acid contributes to memory formation, and specifically the changes that occur during the neural networks during behavioural changes.

我要的设备是一个电生理记录装置。我们进行的电生理记录是脑细胞的电记录，用于测量细胞的活动水平，通过特定膜离子通道的电流流动，以及测量神经网络中不同脑细胞之间的通信。我们正在进行的研究旨在确定维生素A代谢物视黄酸在记忆形成中的作用。阻断视黄酸信号通路会阻碍从软体动物到人类的记忆形成。然而，人们对维甲酸如何影响大脑网络内的突触连接知之甚少。我要求的设备是必要的记录设备，需要升级电生理记录装置，使我能够继续我的NSERC资助的研究。我的NSERC研究的一个重要组成部分是研究维甲酸如何有助于记忆的形成，特别是在行为变化期间神经网络发生的变化。