Exploring the effects of copper-infused fabric on inflammation

探索浸铜织物对炎症的影响

• 批准号: 522164-2018
• 负责人: AbdulSater, Ali
• 金额: $ 1.82万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643328
• 关键词: Exploring; effects; copper; infused; fabric

A plethora of anecdotal evidence points out to the positive benefits of incorporating copper into wearable accessories or drinking**water stored in copper containers in promoting an anti-inflammatory state to alleviate arthritis and other inflammatory diseases. In**fact, while some studies have shown anti-inflammatory effects of copper in animal models and in vitro, other studies have shown**that copper can behave as an inflammatory agent and increase the levels of damaging free radicals. Recently, CuTEC yarn, a bioengineered**copper-infused yarn, is being widely used in fabric to make clothes, bedding sheets, eye masks and braces. These**products, which are also manufactured by Fine Cotton Factory using the CuTEC yarn, are being marketed as having antimicrobial**and anti-inflammatory effects with plenty of testimonials to back these claims. However, solid scientific evidence and mechanistic**insights into how copper-infused yarn possesses anti-inflammatory effects remains lacking. The proposed project will examine the**anti-inflammatory effects of fabric knit from copper-infused yarn and elucidate the underlying mechanisms through which copper**might be mediating its anti-inflammatory properties. Several pro-inflammatory intracellular pathways will be triggered in immune**cells that have been exposed to CuTEC yarn-knit fabric. Pro-inflammatory and anti-inflammatory cytokines will be measured and**activation of these inflammatory pathways will be evaluated. These studies will provide robust scientific evidence to confirm or**refute potential anti-inflammatory properties of copper infused fabric, determine the proportion of CuTEC yarn that is needed to**provide any potential anti-inflammatory benefits, and provide important mechanistic insights for these effects.

大量轶事证据指出，将铜融入可穿戴配件或饮用铜容器中储存的水，可以促进抗炎状态，从而减轻关节炎和其他炎症性疾病的积极益处。事实上，虽然一些研究表明铜在动物模型和体外具有抗炎作用，但其他研究表明铜可以充当炎症剂并增加破坏性自由基的水平。最近，CuTEC 纱线，一种生物工程**注入铜的纱线，被广泛应用于制造衣服、床单、眼罩和牙套的织物中。这些**产品也是由 Fine Cotton Factory 使用 CuTEC 纱线生产的，在市场上被宣传为具有抗菌**和抗炎作用，并有大量的证词支持这些说法。然而，关于铜注入纱线如何具有抗炎作用的可靠科学证据和机制**见解仍然缺乏。拟议的项目将检查由注入铜的纱线编织的织物的抗炎作用，并阐明铜**可能介导其抗炎特性的潜在机制。接触 CuTEC 纱线针织物的免疫细胞将触发多种促炎细胞内途径。将测量促炎和抗炎细胞因子，并评估这些炎症途径的激活。这些研究将提供强有力的科学证据来证实或**反驳铜注入织物的潜在抗炎特性，确定**提供任何潜在抗炎功效所需的 CuTEC 纱线比例，并为这些效果提供重要的机制见解。