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System for testing the dynamic response of human aortas and aortic grafts in an automated mock circulatory loop

用于在自动模拟循环回路中测试人体主动脉和主动脉移植物动态响应的系统

基本信息

批准号：
RTI-2019-00057
负责人：
Amabili, Marco
金额：
$ 10.82万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Research Tools and Instruments
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643843
关键词：
System testing dynamic response human

项目摘要

The requested equipment supports the following research activities of the applicant and of the only co-applicant. 1) System for testing the dynamic response of human aortas and aortic grafts in an automated mock circulatory loop (Prof. Amabili, applicant); 2) Development of a new hubless ventricular assist device (Prof. Mongrain, co-applicant). These researches share the need for an automated mock circulatory loop with closed-loop flow control. This equipment is constituted by a turnkey pulsatile pump reproducing the cardiac action from 0 to 240 BPM. The apparatus will be equipped with confocal lasers for the high-resolution non-contact measurement of the static and dynamic displacements of biomedical samples under internal pressure. This equipment can be used to investigate several characteristics of biomedical structures. It is compact, easy to install and ideal for determining the behaviour of structures under various conditions. It is equipped with several transducers and a dedicated acquisition system for the management of experimental data. It will be a key factor in allowing for the first time the vibrational characterization of the large arteries of the human body or of relevant prostheses. It will be used by four master's students and one post-doctoral fellow working under the supervision of the applicants.

申请的设备支持申请人和唯一共同申请人的以下研究活动。1)用于在自动模拟循环回路中测试人主动脉和主动脉移植物动态响应的系统（Amabili教授，申请人）; 2）开发一种新的无轮毂心室辅助装置（Mongrain教授，共同申请人）。这些研究都需要一个自动模拟循环回路与闭环流量控制。该设备由一个交钥匙脉动泵组成，可再现0至240 BPM的心脏动作。该设备将配备共焦激光器，用于对生物医学样本在内部压力下的静态和动态位移进行高分辨率非接触测量。该设备可用于研究生物医学结构的几个特性。它结构紧凑，易于安装，是确定各种条件下结构性能的理想选择。它配备了多个传感器和一个专用的采集系统，用于管理实验数据。这将是第一次允许人体大动脉或相关假体的振动特性的关键因素。它将由四名硕士生和一名博士后研究员在申请人的监督下工作。