The interactions between phasic and adaptable elements of ocular vergence

眼聚散的阶段性要素和适应性要素之间的相互作用

• 批准号: RGPIN-2016-04404
• 负责人: Bobier, William
• 金额: $ 2.04万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=645675
• 关键词: interactions; between; phasic; adaptable; elements

If I were to consider purchasing a self-driving car I would look carefully at the beyond the rapid transmission speeds, the accurate sensors that would be critical to the servomechanism. Instead I would look beyond the hard wired elements, for a property found most motor systems known as adaptation. Adaptation is the ability to deal with changes over time brought on by many variables such as the rusting of the components of the motor chassis. Human motor adaptation allows adjustment to perturbations in a given reflex system. Motor adaptations have been well studied. Eye movements often provide a model with less complexity then most motor systems as the stimulus and response remain in the domain of one organ. Movements are made by 3 pairs of extraocular muscles which behave similarly. Movements can be represented by 3 orthogonal axes. However, even oculomotor adaptations are known only in terms of changes to the original reflex. Little is known about the motor traits of the adaptive response itself. In the case of ocular convergence; however, the adaptive mechanism acts to replace reflex innervation with increase tonic innervation. This proposal exploits the findings that adaptive changes in the tonic levels of vergence engage after the completion of the reflex movement. This allows a unique view of the adaptive response instead of adaptation being hidden where we see its effects indirectly based upon adjustments original movement. An experimental design was developed to measure the properties of the vergence adaptive response as well as the initial reflex movement. By isolating the dynamic properties of the adaptive response we can now determine its inputs and outputs in order to answer the questions about whether it is influenced by other associated eye movements such as saccades, and whether the vergence adaptive response can act to adjust the original response. . Isolation of the adapted response will also allow anatomical correlates to be identified using approved methods of cranial stimulation (TMS) of the vermis of the cerebellum. From studies of other eye movements, TMS stimulation will be applied in order that adaption is either enhanced or attenuated. Further, tonic adaptation could represent circuitry limited to the midbrain and cerebellum and thus represent a very basic motor element of motor adaptation. The work will be translational since we have shown that reduced vergence adaptation underlies well known clinical conditions such as convergence insufficiency and that vergence adaptation can be restored by through overall remediation using eye excercises.

如果我考虑购买一辆自动驾驶汽车，我会仔细考虑快速传输速度之外的东西，以及对伺服机构至关重要的准确传感器。相反，我会把目光投向硬连线元素之外，寻找一种大多数电机系统都被称为适应的特性。适应能力是处理由许多变量带来的随时间变化的能力，例如发动机底盘部件的生锈。人类的运动适应允许对给定反射系统中的扰动进行调整。运动适应已经得到了很好的研究。眼球运动通常提供一个比大多数运动系统更简单的模型，因为刺激和反应仍然停留在一个器官的领域。运动是由3对眼外肌进行的，它们的行为相似。运动可以用3个正交轴来表示。然而，即使是眼球运动的适应，也只能通过原始反射的变化来了解。人们对适应性反应本身的运动特性知之甚少。然而，在眼球会聚的情况下，适应性机制以增加的紧张性神经支配取代了反射神经支配。这一建议利用了这样的发现，即在反射运动完成后，紧张度水平的适应性变化参与其中。这使得我们可以对适应性反应有一个独特的看法，而不是隐藏适应，在那里我们可以间接地看到基于调整原始运动的影响。开发了一种实验设计来测量收敛适应反应和初始反射运动的特性。通过分离自适应反应的动态特性，我们现在可以确定它的输入和输出，以便回答关于它是否受到其他相关眼球运动(如眼跳)的影响，以及收敛自适应反应是否可以调整原始反应的问题。。适应性反应的分离也将允许使用批准的小脑蠕虫的颅骨刺激(TMS)方法来识别解剖学上的相关性。通过对其他眼球运动的研究，将应用TMS刺激，以增强或减弱适应能力。此外，紧张性适应可能代表仅限于中脑和小脑的回路，因此代表运动适应的一个非常基本的运动元素。这项工作将是翻译的，因为我们已经表明，减少的会聚适应是众所周知的临床情况的基础，例如收敛不足，并且通过使用眼睛摘录进行全面的补救可以恢复会聚适应。