The interactions between phasic and adaptable elements of ocular vergence

眼聚散的阶段性要素和适应性要素之间的相互作用

• 批准号: RGPIN-2016-04404
• 负责人: Bobier, William
• 金额: $ 2.04万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630780
• 关键词: interactions; between; phasic; adaptable; elements

If I were to consider purchasing a self-driving car I would look carefully at the beyond the rapid transmission speeds, the accurate sensors that would be critical to the servomechanism. Instead I would look beyond the hard wired elements, for a property found most motor systems known as adaptation. Adaptation is the ability to deal with changes over time brought on by many variables such as the rusting of the components of the motor chassis. Human motor adaptation allows adjustment to perturbations in a given reflex system. Motor adaptations have been well studied. Eye movements often provide a model with less complexity then most motor systems as the stimulus and response remain in the domain of one organ. Movements are made by 3 pairs of extraocular muscles which behave similarly. Movements can be represented by 3 orthogonal axes. However, even oculomotor adaptations are known only in terms of changes to the original reflex. Little is known about the motor traits of the adaptive response itself. In the case of ocular convergence; however, the adaptive mechanism acts to replace reflex innervation with increase tonic innervation. This proposal exploits the findings that adaptive changes in the tonic levels of vergence engage after the completion of the reflex movement. This allows a unique view of the adaptive response instead of adaptation being hidden where we see its effects indirectly based upon adjustments original movement. An experimental design was developed to measure the properties of the vergence adaptive response as well as the initial reflex movement. By isolating the dynamic properties of the adaptive response we can now determine its inputs and outputs in order to answer the questions about whether it is influenced by other associated eye movements such as saccades, and whether the vergence adaptive response can act to adjust the original response. . Isolation of the adapted response will also allow anatomical correlates to be identified using approved methods of cranial stimulation (TMS) of the vermis of the cerebellum. From studies of other eye movements, TMS stimulation will be applied in order that adaption is either enhanced or attenuated. Further, tonic adaptation could represent circuitry limited to the midbrain and cerebellum and thus represent a very basic motor element of motor adaptation. The work will be translational since we have shown that reduced vergence adaptation underlies well known clinical conditions such as convergence insufficiency and that vergence adaptation can be restored by through overall remediation using eye excercises.

如果我考虑购买一辆自动驾驶汽车，我会仔细研究快速传输速度之外的精确传感器，这对伺服机构至关重要。相反，我会超越硬连线元素，寻找一种被称为适应的大多数运动系统的特性。适应是一种能力，能够处理随着时间的推移所带来的变化，如生锈的汽车底盘的组成部分。人类的运动适应性允许对给定反射系统中的扰动进行调整。运动适应已经得到了很好的研究。眼球运动通常提供了一个模型，其复杂性低于大多数运动系统，因为刺激和反应保持在一个器官的域中。运动是由3对眼外肌，其行为相似。运动可以由3个正交轴表示。然而，即使是视觉适应，也只知道原始反射的变化。人们对适应性反应本身的运动特征知之甚少。然而，在眼睛会聚的情况下，适应机制的作用是用增加的紧张性神经支配代替反射性神经支配。该建议利用了这样的发现，即在反射运动完成后，聚散的紧张水平的自适应变化。这允许对适应性反应的独特看法，而不是隐藏适应性，因为我们间接地看到它的效果是基于调整原始运动的。一个实验设计被开发来测量的聚散度适应性反应以及初始反射运动的属性。通过分离自适应反应的动态特性，我们现在可以确定其输入和输出，以回答有关它是否受到其他相关眼球运动（如扫视）的影响以及聚散度自适应反应是否可以调节原始反应的问题。.适应性反应的分离也将允许使用小脑蚓部的经批准的颅刺激（TMS）方法来识别解剖学相关性。从其他眼球运动的研究中，TMS刺激将被应用，以增强或减弱适应。此外，紧张性适应可能代表局限于中脑和小脑的回路，因此代表了运动适应的一个非常基本的运动元素。这项工作将是翻译，因为我们已经表明，减少聚散适应的基础是众所周知的临床条件，如会聚不足，聚散适应可以通过使用眼睛锻炼的整体补救恢复。