Development of an in vivo imaging system for the chronic study of mouse spinal cord function

开发用于小鼠脊髓功能长期研究的体内成像系统

• 批准号: 529808-2018
• 负责人: Bonin, Robert
• 金额: $ 1.81万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=645782
• 关键词: Development; vivo; imaging; system; chronic

Chronic pain affects up to 1 in 5 adults and places a large economic and social burden on both societies and**individuals. Most of the current therapies for chronic pain are only weakly effective or have debilitating side**effects, such as addiction and withdrawal, that compound the reduced quality of life caused by pain. In this**project we will develop new approaches and devices to advance our understanding of how chronic pain can**arise. In collaboration with the innovative brain imaing company, Mightex, we will create a new system to**directly image the activity of cells in the spinal cord that respond to and process painful stimuli. We will use**this system to explore how the cells of the spinal cord begin to 'misprocess' sensory input in chronic pain, and**examine new approaches to restore normal spinal cord sensory function.

慢性疼痛影响多达五分之一的成年人，给社会和个人带来巨大的经济和社会负担。目前大多数治疗慢性疼痛的方法都是无效的，或者有使人衰弱的副作用，如成瘾和戒断，这加剧了疼痛引起的生活质量下降。在这个项目中，我们将开发新的方法和设备，以促进我们对慢性疼痛如何产生的理解。与创新的大脑成像公司Mightex合作，我们将创建一个新的系统来直接成像脊髓中对疼痛刺激做出反应和处理的细胞的活动。我们将使用这个系统来探索脊髓细胞如何开始“错误处理”慢性疼痛中的感觉输入，并研究恢复正常脊髓感觉功能的新方法。