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NEural MOdulation of IMMUNE system to shape cardiac remodeling to chronic Arterial hypertension and counteract Heart Failure

NEural MOdulation of IMMUNE system to shape cardiac remodeling to chronic Arterial hypertension and counteract Heart Failure
免疫系统的神经调节塑造慢性动脉高血压的心脏重塑并对抗心力衰竭
批准号:
392721
负责人:
Epelman Slava
金额:
$20.4万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-06-01 至 2021-06-01

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中文摘要
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英文摘要
Hypertensive heart disease (HTN-HD) develops secondary to left ventricle (LV) pressure overload and neurohormonal hyperactivation induced by hypertension (HTN). Chronic HTN-HD leads to heart failure (HF) with a preserved ejection fraction (HFpEF). Despite
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Differential type I interferon responses drive sex-specific vulnerability to viral myocarditis
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Cardioprotection during hypertensive heart disease is mediated through anti-viral cytokine pathways
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An unexpected role for type I Interferon underlies cardiac adaptation to stress and prevents heart failure
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