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An unexpected role for type I Interferon underlies cardiac adaptation to stress and prevents heart failure

An unexpected role for type I Interferon underlies cardiac adaptation to stress and prevents heart failure
I 型干扰素在心脏适应压力和预防心力衰竭方面发挥着意想不到的作用
批准号:
444878
负责人:
Epelman Slava
金额:
$66.32万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-04-01 至 2026-04-01

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中文摘要
翻译
高血压(HTN)可导致心脏结构和功能的有害改变,这一过程被称为高血压性心脏病(HTN-HD)。免疫系统指导HTN-HD过程中触发的无菌炎症反应;然而,目前尚不清楚
英文摘要
Hypertension (HTN) can leads to detrimental changes the structure and function of the heart, a process termed hypertensive heart disease (HTN-HD). The immune system directs the sterile inflammatory response triggered during HTN-HD; however, it is unclear
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会议论文
Differential type I interferon responses drive sex-specific vulnerability to viral myocarditis
  • 批准号:
    487141
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2023
  • 负责人:
    Epelman Slava
  • 依托单位:
Differential type I interferon responses drive sex-specific vulnerability to viral myocarditis
  • 批准号:
    488319
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.32万
  • 财政年份:
    2023
  • 负责人:
    Epelman Slava
  • 依托单位:
Cardioprotection during hypertensive heart disease is mediated through anti-viral cytokine pathways
  • 批准号:
    461883
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.6万
  • 财政年份:
    2022
  • 负责人:
    Epelman Slava
  • 依托单位:
Cerebrovascular-immune interfaces: searching for an immune signature coupling hypertension to cognitive dysfunction (ImmuneHyperCog).
  • 批准号:
    425187
  • 项目类别:
    Operating Grants
  • 资助金额:
    $21.86万
  • 财政年份:
    2020
  • 负责人:
    Epelman Slava
  • 依托单位:
海外基金