Impact of vitamin supplements (vitamin D, E and C) on antioxidant status and inflammatory response in pigs fed deoxynivalenol contaminated diets

本项目的总体目的是研究维生素补充剂（维生素D、E和C）对饲喂脱氧雪腐烯醇（DON）污染日粮的猪的抗氧化状态和炎症反应的影响。具体来说，目的是1-确定DON对猪体内维生素D代谢的影响；2 .评价维生素D、E和C对don污染日粮猪抗氧化状态和炎症反应的影响。事实上，即使已知DON可以影响抗氧化和免疫状态，但DON对维生素代谢，特别是维生素D的具体影响尚不清楚。此外，一些维生素，如维生素E和C，可以有效地减少DON对抗氧化状态的负面影响，但这些维生素对饲喂DON污染日粮的猪的维生素D代谢的潜在影响需要确定。本项目获得的结果将对更好地利用霉菌毒素污染饲料，特别是含DON的饲料产生短期和长期影响。该项目还将开展几个领域的研究，以了解DON对维生素代谢、抗氧化和免疫状态影响的潜在机制，从而了解维生素补充剂对动物这些状态的影响。最后，通过制定新的策略来有效地利用受污染的饲料，该项目将有助于更有效地利用饲料资源和发展养殖技术，以保持加拿大养猪业的竞争力。

The general purpose of this project is to study the impact of vitamin supplements (vitamin D, E and C) on antioxidant status and inflammatory response in pigs fed deoxynivalenol (DON)-contaminated diets. Specifically, the objectives are 1- to determine the effects of DON on metabolism of vitamin D in pigs; 2-to evaluate the effect vitamin D, E and C on antioxidant status and inflammatory response in pigs fed DON-contaminated diet. In fact, even if it is know that DON can affect the antioxidant and immune status, the specific effects of DON on the vitamin metabolism, especially the vitamin D, were not clearly known. Furthermore, some vitamins, like vitamins E and C, can be effective in reducing negative effects of DON on antioxidant status, but the potential effect of these vitamins on the vitamin D metabolism in pigs fed DON-contaminated diets need to be determined. The results obtained in this project will have a short and long term impact to a better use of mycotoxin contaminated feeds, especially with DON. This project will also open several areas of investigation that will allow to understand the underlying mechanisms of the effect of DON on vitamin metabolism and antioxidant and immune status, and thus the effects of vitamin supplements on these status in the animal. Finally, by developing new strategies to use efficiently contaminated feed this project will contribute to use more efficiently feed resources and develop farming techniques to maintain the competitiveness of Canadian swine industry.