Exploration of new chemicals to enable rapid functionalization of pharmaceuticals**

探索新化学品以实现药物的快速功能化**

• 批准号: 537314-2018
• 负责人: Li, ChaoJun
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657424
• 关键词: Exploration; new; chemicals; enable; rapid

Paraza Pharma intends to diversify pharmaceutical molecules/intermediates for rapid Structure-Activity-Relationship (SAR) studies. However, the current methodologies lacks the compatibility of many functional groups which usually exist in advance pharmaceutical intermediate. Furthermore, many pharmaceutical interesting fragments requires multiple steps to be introduced into the pharmaceutical intermediates. The proposed project will address this problem using novel alkylating reactions recently discovered in Professor Chao-Jun Li's laboratory. The project will pursue new chemical matters which will allow the functionalization of advance pharmaceuticals in one step. The research will be focusing on optimizing reaction conditions to allow chemo-selective and functional group tolerable transformation possible. ****The success of this proposed project will be a significant advancement in pharmaceutical industry research and development.**

Paraza Pharma打算多样化药物分子/中间体，以进行快速结构 - 活性关系（SAR）研究。但是，当前的方法缺乏许多官能团的兼容性，这些官能团通常存在于药物中间体。 此外，许多药物有趣的片段需要将多个步骤引入药物中间体。拟议的项目将使用最近在Chao-Jun Li的实验室中发现的新烷基化反应来解决这个问题。该项目将寻求新的化学事务，这将允许在一步中实现预先药品的功能。该研究将重点放在优化反应条件上，以使化学选择性和功能群可以忍受转化。 ****这个拟议项目的成功将是制药行业研发的重大进步。**