Functional Organization of Non-Primary Auditory Cortex

非初级听觉皮层的功能组织

• 批准号: RGPIN-2016-05049
• 负责人: Lomber, Stephen
• 金额: $ 6.63万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657933
• 关键词: Functional; Organization; Non; Primary; Auditory

Functional specialization is a common characteristic of the cerebral cortex. Globally, regions are specialized to perform particular sensory or motor functions. Within extrastriate visual cortex of humans, monkeys and cats, areas have been identified that are further specialized for spatial, motion, and pattern processing. The behavioural correlate for such functional specializations, or a “division of labour”, within auditory cortex is largely unknown. The long-term goal of our research program is to elucidate the behavioral “division of labour” within cat auditory cortex and determine the relative contributions that the different auditory fields make to acoustically-mediated behaviors. These results, when combined with investigations of underlying neuronal activity and cerebral connections, will provide evidence for, or refute, which hierarchical or network theories best explain processing in auditory cortex.***In the proposed study, we combine a battery of behavioural tests, electrophysiological recording, and reversible deactivation to dissect the functional plan of auditory cortex. This project will examine the 13 regions of acoustically-responsive cortex: the four tonotopic fields (AI, AAF, PAF & VPAF) and nine non-tonotopic areas (AII, FAES, dPE, iPE, vPE, DZ, VAF, IN, & T). In the proposed experiments we will emphasize pattern and temporal processing in auditory cortex. We hypothesize that the use of the proposed tasks and stimuli will reveal, both behaviorally and electrophysiologically, that areas along the dorso-ventral plane have increasing stimulus specificity similar to that of the ventral “what” processing stream in extrastriate visual cortex.***Overall, we plan to produce the first compendium of the multiple, yet unique, combinations of neural contributions each region of auditory cortex makes to the processing of pattern and temporal stimuli. The results from these studies are essential for the development of functionally-based models of cerebral operations that will form the foundation of future knowledge of emergent and higher-order integrative processes.********

功能专门化是大脑皮层的共同特征。在全球范围内，区域是专门执行特定的感觉或运动功能的。在人类、猴子和猫的外层视觉皮层中，已经确定了进一步专门用于空间、运动和模式处理的区域。在听觉皮层中，这种功能专门化或“劳动分工”的行为关联在很大程度上是未知的。我们的研究计划的长期目标是阐明猫听觉皮层内的行为“分工”，并确定不同的听觉场对声音介导行为的相对贡献。这些结果，当结合对潜在的神经元活动和大脑连接的调查，将提供证据，或反驳，层次或网络理论最好地解释听觉皮层的处理。在拟议的研究中，我们结合了一系列的行为测试、电生理记录和可逆失活来解剖听觉皮层的功能计划。该项目将检查13个声响应皮层区域：四个音调区域（AI， AAF， PAF和VPAF）和九个非音调区域（AII， FAES, dPE, iPE, vPE， DZ， VAF， IN, & T）。在拟议的实验中，我们将强调听觉皮层的模式和时间处理。我们假设，这些任务和刺激的使用将在行为学和电生理学上揭示，背-腹侧平面上的区域具有与腹侧的“什么”处理流类似的刺激特异性。***总的来说，我们计划对听觉皮层的每个区域对模式和时间刺激的处理所做出的多种而独特的神经贡献组合做出第一个纲要。这些研究的结果对于基于功能的大脑操作模型的发展至关重要，这些模型将为未来的紧急和高阶整合过程知识奠定基础。********